DNA Polymerase iota
This antibody reacts specifically with DNA Polymerase iota
KLH conjugated synthetic peptide derived from human DNA Polymerase iota
DNA polymerase activity is essential for replication, repair, recombination and mutagenesis. DNA polymerases can often bypass DNA lesions that block DNA replication, thereby allowing the replication of damaged DNA. One such DNA polymerase is the distributive enzyme DNA Pol i, which is encoded by the POLI gene. POLI is located on human chromosome 18q21.2, a region often implicated in the etiology of many human cancers. At thymine templates, DNA Pol i is highly error-prone when replicating undamaged DNA in that it favors the misincorporation of guanine over the correct nucleotide, adenosine. DNA Pol i also promotes the replication of damaged DNA by misincorporating deoxynucleotides opposite DNA lesions. DNA Pol i acts sequentially with DNA Pol Î©, which is essential for damage-induced mutagenesis, to complete the DNA lesion bypass. Therefore, replication involving DNA Pol i is likely to be highly mutagenic.
DNA polymerase iota; Eta 2; Eta2; POLI; POLI_HUMAN; Polymerase DNA directed iota; RAD 30B; RAD30 homolog B; RAD30B; RAD3OB.
Also known as
DNA Polymerase iota Polyclonal Antibody
Anti-DNA Polymerase iota Polyclonal
For facs or microscopy Alexa 1 conjugate.
Alexa Fluor,ALEXA FLUOR® 594
Alexa conjugate 1
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Polyclonals and antibodies
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
Anti-DNA Polymerase iota
Polyclonal, anti, dna
DNA Polymerase iota Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
Long gene name protein kinase, DNA-activated, catalytic subunit
Synonyms gene name
- protein kinase, DNA-activated, catalytic polypeptide
- DNA-dependent protein kinase catalytic subunit
Discovery year 1993-11-09
Entrez gene record 5591
- Armadillo like helical domain containing
Havana BLAST/BLAT OTTHUMG00000164239
Long gene name DNA polymerase iota
Synonyms gene name
- polymerase (DNA directed) iota
- polymerase (DNA) iota
Discovery year 2000-01-24
Entrez gene record 11201
Havana BLAST/BLAT OTTHUMG00000132704