HLA-B (MHC Class I) Mouse Monoclonal Antibody

  • Catalog number
    MBS439751
  • Price
    Please ask
  • Size
    0.02 mg (With BSA & Azide at 0.2mg/mL)
  • Products_type
    Antibody
  • Products_short_name
    [HLA-B]
  • Products_name_syn
    [HLA-B, HLAB, MHC Class I HLA heavy chain, Leukocyte antigen class I-B]
  • Other_names
    [HLA class I histocompatibility antigen, B-27 alpha chain; HLA class I histocompatibility antigen, B-27 alpha chain; major histocompatibility complex, class I, B; major histocompatibility complex, class I, B; MHC class I antigen B*27]
  • Products_gene_name
    [HLA-B]
  • Other_gene_names
    [HLA-B; HLA-B; AS; HLAB; Bw-47; Bw-50; SPDA1; B-4901; B-5001; HLA-Cw; HLA-B15; HLA-B39; HLA-B49; HLA-B50; HLA-B55; HLA-B59; HLA-B61; HEL-S-83; HLA-DRB1; HLA-B*45ZJ; HLA-B-3506; HLA-B-3905; HLA-B-5502; HLA-B-5602; HLAB]
  • Clonality
    Monoclonal
  • Clone
    [SPM420]
  • Reactivity
    Human
  • Specificity
    HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
  • Form
    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
  • Storage_stability
    Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
  • Tested_application
    Flow Cytometry (FC/FACS), Immunofluorescence (IF)
  • Properties
    If you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • About
    Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
  • Test
    Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
  • Latin name
    Mus musculus
  • French translation
    anticorps
  • Gene target
    HLA-B   MHC   Class   Monoclonal  
  • Gene symbol
    HLA-B, HLA-DPA2, HLA-DOA, HLA-DQA1, HLA-N, HLA-DPB1, HLA-DQA2, HLA-DQB2, HLA-W, HLA-DRA
  • Short name
    HLA-B (MHC Class I) Mouse Monoclonal Antibody
  • Technique
    Mouse monoclonal, Antibody, Mouse, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
  • Host
    Mouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
  • Isotype
    IgG3, kappa
  • Species
    Mouse, Mouses
  • Alternative name
    major histocompatibility complex, class I, B (Major histocompabitility complex Class I) Mouse monoclonal (antibody to-)
  • Alternative technique
    antibodies, murine
  • Alternative to gene target
    major histocompatibility complex, class I, B, AS and HLAB and SPDA1, HLA-B and IDBG-299578 and ENSG00000234745 and 3106, peptide antigen binding, Cell surfaces
Gene info
  • Identity
    HGNC:4932
  • Gene
    HLA-B
  • Long gene name
    major histocompatibility complex, class I, B
  • Synonyms gene
  • Synonyms gene name
    • ankylosing spondylitis
  • GenBank acession
  • Locus
    6p21.33
  • Discovery year
    2001-06-22
  • Entrez gene record
    3106
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • C1-set domain containing
    • Histocompatibility complex
    • MicroRNA protein coding host genes
  • VEGA ID
    OTTHUMG00000031153
  • Locus Specific Databases
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
MeSH Data
  • Name
    Blood Grouping and Crossmatching
  • Concept
    Scope note: Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion.
  • Tree numbers
    • E01.370.225.625.120
    • E01.370.225.812.385.120
    • E05.200.625.120
    • E05.200.812.385.120
    • E05.478.594.385.120
  • Qualifiers
    ethics, mortality, psychology, trends, veterinary, history, classification, economics, instrumentation, methods, nursing, standards, adverse effects, statistics & numerical data
Product images
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HLA B MHC Class I Mouse Monoclonal Antibody - Gentaur.com
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