DP-4978

• Catalog number
  B1288-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea; LY3009120
• Description
  DP-4978 is a potent and selective pan-RAF inhibitor with potential anticancer activity. DP-4978 displays activities against B-Raf or Ras mutant tumor cells. It binds to A-Raf, B-Raf and C-Raf isoforms with similar affinity in cells with activating mutations of B-Raf or K-Ras.
• CAS Number
  1454682-72-4
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₃H₂₉FN6O
• Molecular Weight
  424.52
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A potent and selective pan-RAF inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  71721540
• PubChem CID Link
• SMILES
  CC1=CC(=C(C=C1C2=C(N=C3C(=C2)C=NC(=N3)NC)C)NC(=O)NCCC(C)(C)C)F
• InChi
  InChI=1S/C23H29FN6O/c1-13-9-18(24)19(29-22(31)26-8-7-23(3,4)5)11-16(13)17-10-15-12-27-21(25-6)30-20(15)28-14(17)2/h9-12H,7-8H2,1-6H3,(H2,26,29,31)(H,25,27,28,30)
• InChi Key
  HHCBMISMPSAZBF-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  DP-4978  
• Gene symbol
  TFDP2, PTGDR, TFDP1
• Short name
  DP-4978
• Alternative name
  DP-4978

Gene info

• Identity
  HGNC:11751
• Gene
  TFDP2
• Long gene name
  transcription factor Dp-2
• Synonyms gene name
  • transcription factor Dp-2 (E2F dimerization partner 2)
• Synonyms
  • Dp-2
• Synonyms name
  • E2F dimerization partner 2
• GenBank acession
  • U18422
• Locus
  3q23
• Discovery year
  1995-12-15
• Entrez gene record
  7029
• Pubmed identfication
  • 7784053
  • 9027491
• RefSeq identity
  • NM_006286
• Classification
  • Transcription factor Dp family
• VEGA ID
  OTTHUMG00000164975

Gene info

• Identity
  HGNC:9591
• Gene
  PTGDR
• Long gene name
  prostaglandin D2 receptor
• Synonyms
  • DP
  • DP1
  • PTGDR1
• GenBank acession
  • U31332
• Locus
  14q22.1
• Discovery year
  1995-11-09
• Entrez gene record
  5729
• Pubmed identfication
  • 7642548
• RefSeq identity
  • NM_000953
• Classification
  • Prostaglandin receptors
• VEGA ID
  OTTHUMG00000140299

Gene info

• Identity
  HGNC:11749
• Gene
  TFDP1
• Long gene name
  transcription factor Dp-1
• Synonyms
  • Dp-1
  • DRTF1
  • DP1
  • DILC
• Synonyms name
  • down-regulated in liver cancer stem cells
• GenBank acession
  • BC011685
• Locus
  13q34
• Discovery year
  1995-02-02
• Entrez gene record
  7027
• Pubmed identfication
  • 8413592
  • 9027491
• RefSeq identity
  • NM_007111
• Classification
  • Transcription factor Dp family
• VEGA ID
  OTTHUMG00000017388

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