APEX2 Antibody

• Catalog number
  R30568
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  APEX2
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P
• Recommended dilutions
  Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the APEX2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This APEX2 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q9UBZ4
• Purity
  Antigen affinity
• Description
  Apurinic/apyrimidinic endonuclease like-2 is a member of the apurinic/apyrimidinic (AP) family of endonucleases that initiate the repair of AP sites formed by spontaneous hydrolysis of the N-glycosylic bond, mutagen-induced base release, or damaged-base excision by a DNA repair glycosylase. RT-PCR detected expression in HeLa cells, Jurkat cells, and human kidney, brain and fetal brain tissue. The APEX2 gene contains 6 exons and is mapped to chromosome Xp11.21. It participates in both nuclear and mitochondrial base excision repair (BER). APEX2 displayed weaker AP site-specific and 3-prime nuclease activities compared to APEX1. The protein plays a role in processing 3-prime-damaged termini or 3-prime-mismatched nucleotides.
• Immunogen
  An amino acid sequence from the C-terminus of human APEX2 (DPSSRCNFFLWSRPS) was used as the immunogen for this APEX2 antibody (100% homologous in human, mouse and rat).
• Storage
  After reconstitution, the APEX2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  APEX2  
• Gene symbol
  APEX2
• Short name
  Anti-APEX2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to APEX2
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:17889
• Gene
  APEX2
• Long gene name
  apurinic/apyrimidinic endodeoxyribonuclease 2
• Synonyms gene name
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2
• Synonyms
  • APEXL2
  • APE2
  • XTH2
  • ZGRF2
• Synonyms name
  • zinc finger, GRF-type containing 2
• GenBank acession
  • AB021260
• Locus
  Xp11.21
• Discovery year
  2002-07-22
• Entrez gene record
  27301
• Pubmed identfication
  • 11376153
• Classification
  • Zinc fingers GRF-type
• VEGA ID
  OTTHUMG00000021642
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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