p63 Antibody, ALEXA FLUOR 488

• Catalog number
  bs-0723R-A488
• Price
  Please ask
• Size
  100ul

• Long name
  p63 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated
• Also known as
  Anti-p63 PAb ALEXA FLUOR 488
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 488
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  p63
• Specificity
  This is a highly specific antibody against p63.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  370-420/680
• Subcellular location
  Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human p63 protein
• Gene ID Number
  8626
• Swiss Prot
  Q9H3D4
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  499nm/519nm
• Synonyms
  AIS; KET; LMS; NBP; RHS; p4; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B); Tumor protein 63; Chronic ulcerative stomatitis protein; CUSP; Keratinocyte transcription factor KET; Transformation-related protein 63; TP63; Tumor protein p73-like
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-p63 has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor
• French translation
  anticorps

• Gene target
  p63  
• Gene symbol
  TPRG1LP1, CKAP4, TP63
• Short name
  Anti-p63
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 488
• Alternative name
  p63 Polyclonal Antibody, ALEXA FLUOR 488
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:52353
• Gene
  TPRG1LP1
• Long gene name
  tumor protein p63 regulated 1 like pseudogene 1
• Locus
  19q13.43
• Discovery year
  2016-07-28
• Entrez gene record
  100130490
• VEGA ID
  OTTHUMG00000183473

Gene info

• Identity
  HGNC:16991
• Gene
  CKAP4
• Long gene name
  cytoskeleton associated protein 4
• Synonyms gene name
  • cytoskeleton-associated protein 4
• Synonyms
  • P63
  • CLIMP-63
  • ERGIC-63
• GenBank acession
  • X69910
• Locus
  12q23.3
• Discovery year
  2001-11-14
• Entrez gene record
  10970
• Pubmed identfication
  • 8314870
• VEGA ID
  OTTHUMG00000170085

Gene info

• Identity
  HGNC:15979
• Gene
  TP63
• Long gene name
  tumor protein p63
• Synonyms gene
  • TP73L
  • TP53L
  • TP53CP
• Synonyms gene name
  • tumor protein p73-like
  • tumor protein p53-like
  • tumor protein p53-competing protein
• Synonyms
  • p51
  • SHFM4
  • EEC3
  • p63
  • p73L
  • OFC8
  • KET
  • p73H
  • NBP
  • p53CP
• GenBank acession
  • AB010153
• Locus
  3q28
• Discovery year
  2002-04-18
• Entrez gene record
  8626
• Pubmed identfication
  • 9774969
  • 9662378
  • 11181441
  • 11181451
• RefSeq identity
  • NM_003722
• Classification
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000156313
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_428

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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