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Gene info
Fas-associated phosphatase-1 (FAP-1), a NT7 non-receptor protein tyrosine phosphatase, is comprised of a N-terminal FERM domain, five PDZ domains, and a C-terminal tyrosine phosphatase domain. The protein has been shown to bind the cytosolic tail of Fas (Apo1, CD95) and regulate Fas-induced apoptosis. Human tumor cell lines become resistant to Fas-mediated apoptosis when transfected with FAP-1, indicating that FAP-1 functions as a negative regulator in Fas-mediated death signaling. FAS resistance has been documented in a variety of cancers, including cancer of the lung, ovary, pancreas, and liver. At least three protein isoforms of FAP-1 have been reported. Alterations in FAP-1 expression have been shown to result in defects in cytokinesis.
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Gene names
PTPN13, FAP-1, HPTP1E, HPTPE1, Fas associated phosphatase 1, Phosphatase rip, PTP-BAS, PTP-E1, PTP-BL, PTP1E, PTPLE, PNP1, PTPL1
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Antibodie s label
unlabelled serum
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Purity
Protein G Column
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Ab raised in
Rabbit
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Type
Polyclonal
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Antigen
Amino acids 2451 to 2466 of human PTPN13
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Immuno application
ELISA, immuno-histo-chemistry
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Antibody advice
PTPN13 antibody can be used in ELISA starting at 1:10000 - 1:50000, Western Blot starting at 1:5000 - 1:10000, and immunohistochemistry starting at 1:500.
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Suspention pH azide
PBS, 0.1% sodium azide.
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Keep at
PTPN13 antibody should be stored long term (months) at -20 grades C and short term (weeks) at 4 grades C. As with all antibodies avoid freeze/thaw cycles.
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Works with
Human
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Omim nr
12643716
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Ncbi nr
Q12923
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Vial with antibody
in solution
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NCBI GENE nr
5783
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GENE symbol
PTPN13
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Antigene name
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
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Source
Homo sapiens
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Protein nr
Q12923
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
PTPN13
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Short name
anti-PTPN13 Antibody
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative name
Antibody toprotein tyrosine phosphatase, non-receptor classification 13 (APO-1/CD95 (Fas (tumor necrosis factor receptor superfamily, member 6))-associated phosphatase) (antibody to-)
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Alternative technique
antibodies
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Alternative to gene target
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase), FAP-1 and hPTP1E and PNP1 and PTP-BAS and PTP-BL and PTP1E and PTPL1 and PTPLE, PTPN13 and IDBG-28517 and ENSG00000163629 and 5783, phosphatase activity, nuclei, Ptpn13 and IDBG-184669 and ENSMUSG00000034573 and 19249, BT.64781 and IDBG-643280 and ENSBTAG00000014947 and 282333
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