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Target antigen
CCL3
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human
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Analyses
WB,ELISA
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Immunogen
E.coli-derived rat CCL3 recombinant protein (Position: A24-A92). Rat CCL3 shares 74% and 91% amino acid (aa) sequences identity with human and mouse CCL3, respectively.
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Product configuration
Each vial contains 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the CCL3 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The CCL3 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
Macrophage inflammatory protein-1 alpha (MIP-1 alpha), also called CCL3, LD78. The cDNA for CCL3 predicts a mature peptide of 69 amino acids with a molecular mass of 7,889 daltons. CCL3 is a member of a newly identified superfamily of small inducible proteins involved in inflammatory responses, wound healing and tumorigenesis. CCL3 is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. It constitutes an important second signal for mast cell degranulation in the conjunctiva in vivo and consequently for acute-phase disease.
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Related articles
1. Wolpe, S. D.; Cerami, A. Macrophage inflammatory proteins 1 and 2: members of a novel superfamily of cytokines. FASEB J. 3: 2565-2573, 1989. 2. Nakao, M.; Nomiyama, H.; Shimada, K. Structures of human genes coding for cytokine LD78 and their expression. Molec. Cell. Biol. 10: 3646-3658, 1990. 3. Cook, D. N.; Beck, M. A.; Coffman, T. M.; Kirby, S. L.; Sheridan, J. F.; Pragnell, I. B.; Smithies, O. Requirement of MIP-1-alpha for an inflammatory response to viral infection. Science 269: 1583-1585, 1995. 4. Miyazaki, D.; Nakamura, T.; Toda, M.; Cheung-Chau, K.-W.; Richardson, R. M.; Ono, S. J. Macrophage inflammatory protein-1-alpha as a costimulatory signal for mast cell-mediated immediate hypersensitivity reactions. J. Clin. Invest. 115: 434-442, 2005.
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Gene Name
CCL3
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Protein Name
C-C motif chemokine 3
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Gene Full Name
chemokine (C-C motif) ligand 3
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Synonyms
C C motif chemokine 3 antibody|CCL 3 antibody|CCL3 antibody|CCL3_HUMAN antibody|Chemokine C|C motif ligand 3 antibody|Chemokine CC Motif Ligand 3 antibody|G0/G1 switch regulatory protein 19 1 antibody|G0/G1 switch regulatory protein 19-1 antibody|G0S19 1 antibody|G0S19 1 protein antibody|Heparin binding chemotaxis protein antibody|L2G25B antibody|LD78 alpha antibody|LD78-alpha(4-69) antibody|LD78ALPHA antibody|Macrophage inflammatory protein 1 alpha antibody|Macrophage inflammatory protein 1-alpha antibody|MIP 1 alpha antibody|MIP 1A antibody|MIP-1-alpha antibody|MIP-1-alpha(4-69) antibody|MIP1A antibody|PAT 464.1 antibody|SCYA 3 antibody|SCYA3 antibody|SIS alpha antibody|SIS beta antibody|SIS-beta antibody|Small inducible cytokine A3 antibody|Small-inducible cytokine A3 antibody|Tonsillar lymphocyte LD78 alpha protein antibody
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Uniprot ID
P50229
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Entrez GeneID
25542
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
