H-1152 Dihydrochloride

• Catalog number
  H011520
• Price
  Please ask
• Size
  1 mg

• Chemical available in other sizes
  Please inquire size and price
• Stock availability
  In Stock
• Cas number
  871543-07-6
• Chemical s molecular weight
  392.34
• Chemical s main applications
  ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki=630nM for PKA 9.27 mMfor PKC, and 10.1mM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50=2.5nM) in NT-2 cells.
• Chemical s category
  Inhibitors, Protein Kinase Inhibitors and Activators, Pharmaceuticals, Intermediates & Fine Chemicals
• Other name
  5-[[(2S)-Hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-methylisoquinoline Hydrochloride; (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]Homopiperazine Dihydrochloride;
• Chemical s formula
  C16H23Cl2N3O2S
• Physical properties
  White to Off-White Solid
• Melting temperature
  182-184°C
• Boiling temperature
  No Data Available
• Chemical s soluble in
  Methanol, Water
• Stability conditions
  No Data Available
• Storage
  Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Chemical s specifications

• Gene target
  H-1152   Dihydrochloride  
• Gene symbol
  NCAPH, HLA-H, IGHV3-69-1, FUT1, PIGH, NEFH, ATCAY, RAB11B, RAB35, HFE
• Short name
  H-1152 Dihydrochloride
• Alternative name
  H-1152 Dihydrochloride

Gene info

• Identity
  HGNC:1112
• Gene
  NCAPH
• Long gene name
  non-SMC condensin I complex subunit H
• Synonyms gene
  • BRRN1
• Synonyms gene name
  • barren (Drosophila) homolog
  • barren homolog (Drosophila)
  • barren homolog 1 (Drosophila)
  • non-SMC condensin I complex, subunit H
• Synonyms
  • CAP-H
  • hCAP-H
• GenBank acession
  • BC024211
• Locus
  2q11.2
• Discovery year
  1998-02-11
• Entrez gene record
  23397
• Pubmed identfication
  • 9417923
• RefSeq identity
  • NM_015341
• Classification
  • Condensin I subunits
  • Kleisins
• VEGA ID
  OTTHUMG00000130451

Gene info

• Identity
  HGNC:4965
• Gene
  HLA-H
• Long gene name
  major histocompatibility complex, class I, H (pseudogene)
• GenBank acession
  • M31944
• Locus
  6p22.1
• Discovery year
  1991-08-01
• Entrez gene record
  3136
• Pubmed identfication
  • 1517564
  • 2294403
• RefSeq identity
  • NR_001434
• Classification
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031160
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:5631
• Gene
  IGHV3-69-1
• Long gene name
  immunoglobulin heavy variable 3-69-1 (pseudogene)
• Synonyms gene
  • IGHV3-H
• Synonyms gene name
  • immunoglobulin heavy variable 3-H (provisional)
  • immunoglobulin heavy variable 3-H pseudogene (provisional)
  • immunoglobulin heavy variable 3-H (pseudogene)
• Synonyms
  • IGHV3-h
• GenBank acession
  • AJ879484
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28402
• Pubmed identfication
  • 16133446
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000191145

Gene info

• Identity
  HGNC:4012
• Gene
  FUT1
• Long gene name
  fucosyltransferase 1 (H blood group)
• Synonyms gene
  • H
  • HSC
• Synonyms gene name
  • fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, Bombay phenotype included)
  • fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase)
• Synonyms name
  • galactoside 2-alpha-L-fucosyltransferase
• Locus
  19q13.33
• Discovery year
  1989-06-06
• Entrez gene record
  2523
• RefSeq identity
  • NM_000148
• Classification
  • Fucosyltransferases
  • Blood group antigens
• VEGA ID
  OTTHUMG00000183325
• Locus Specific Databases
  • Blood Group Antigen Mutation Database
  • LRG_810

Gene info

• Identity
  HGNC:8964
• Gene
  PIGH
• Long gene name
  phosphatidylinositol glycan anchor biosynthesis class H
• Synonyms gene name
  • phosphatidylinositol glycan, class H
• Synonyms
  • GPI-H
• Synonyms name
  • phosphatidylinositol N-acetylglucosaminyltransferase subunit
• Locus
  14q24.1
• Discovery year
  1994-09-06
• Entrez gene record
  5283
• Pubmed identfication
  • 8204896
• RefSeq identity
  • NM_004569
• Classification
  • Phosphatidylinositol glycan anchor biosynthesis
• VEGA ID
  OTTHUMG00000171806

Gene info

• Identity
  HGNC:7737
• Gene
  NEFH
• Long gene name
  neurofilament heavy chain
• Synonyms gene name
  • neurofilament, heavy polypeptide 200kDa
  • neurofilament heavy polypeptide
  • neurofilament heavy
• Synonyms
  • NF-H
  • NFH
• Locus
  22q12.2
• Discovery year
  1988-08-31
• Entrez gene record
  4744
• RefSeq identity
  • NM_021076
• Classification
  • Intermediate filaments Type IV
• VEGA ID
  OTTHUMG00000151155
• Locus Specific Databases
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database

Gene info

• Identity
  HGNC:779
• Gene
  ATCAY
• Long gene name
  ATCAY kinesin light chain interacting caytaxin
• Synonyms gene name
  • ataxia, cerebellar, Cayman type
  • ATCAY, caytaxin
• Synonyms
  • BNIP-H
• Synonyms name
  • Cayman ataxia
  • caytaxin
• Locus
  19p13.3
• Discovery year
  1997-01-10
• Entrez gene record
  85300
• Pubmed identfication
  • 8845847
  • 14556008
• Classification
  • BCH domain containing
• VEGA ID
  OTTHUMG00000181836

Gene info

• Identity
  HGNC:9761
• Gene
  RAB11B
• Long gene name
  RAB11B, member RAS oncogene family
• Synonyms
  • H-YPT3
• GenBank acession
  • X79780
• Locus
  19p13.2
• Discovery year
  1999-02-23
• Entrez gene record
  9230
• Pubmed identfication
  • 7811277
• RefSeq identity
  • NM_004218
• Classification
  • RAB, member RAS oncogene GTPases
• VEGA ID
  OTTHUMG00000182278

Gene info

• Identity
  HGNC:9774
• Gene
  RAB35
• Long gene name
  RAB35, member RAS oncogene family
• Synonyms
  • H-ray
• GenBank acession
  • X79781
• Locus
  12q24.23
• Discovery year
  1999-09-29
• Entrez gene record
  11021
• Classification
  • RAB, member RAS oncogene GTPases
• VEGA ID
  OTTHUMG00000169159

Gene info

• Identity
  HGNC:4886
• Gene
  HFE
• Long gene name
  homeostatic iron regulator
• Synonyms gene name
  • hemochromatosis
• Synonyms
  • HLA-H
  • HFE1
• Synonyms name
  • high Fe
• Locus
  6p22.2
• Discovery year
  1986-01-01
• Entrez gene record
  3077
• Pubmed identfication
  • 3460331
  • 28474781
  • 9054933
• Classification
  • C1-set domain containing
• VEGA ID
  OTTHUMG00000016348
• Locus Specific Databases
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database
  • LRG_748

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