Biotin-VDVAD-FMK

• Catalog number
  1032-20C
• Price
  Please ask
• Size
  20 ul (10 mM)

• Alternative_name
  Biotin-VDVAD-FMK, VDVAD-FMK, Biotin
• Description
  This is a synthetic peptide that irreversibly inhibits caspase-2 and related caspase activity. It is a biotinylated derivative of the Caspase-2 inhibitor Z-VDVAD-FMK (Cat # 1142). This conjugation with biotin allows detection of activated caspases in conjunction with avidin-tags. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
• Structure Available
  No
• Peptide sequence
  Biotin-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK
• Salt Form
  No
• Molecular Formula
  C₄₀H₆₅FN₈O₁₂S
• Molecular Weight
  901.05
• Cell Permeable
  Yes
• Purity
  Single spot by TLC
• Handling
  Protect from light and moisture
• Tag Line
  A Caspase-2 inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• SMILES
  O=C(OC)C[C@H](NC([C@@H](NC(C(C(C)C)NC([C@@H](NC(C(C(C)C)NC(CCCCCNC(CCCC[C@H]1SC[C@](N2)([H])[C@@]1([H])NC2=O)=O)=O)=O)CC(OC)=O)=O)=O)C)=O)C(CF)=O
• InChi
  InChI=1S/C40H65FN8O12S/c1-21(2)33(47-30(52)15-9-8-12-16-42-29(51)14-11-10-13-28-35-26(20-62-28)46-40(59)49-35)39(58)45-25(18-32(54)61-7)37(56)48-34(22(3)4)38(57)43-23(5)36(55)44-24(27(50)19-41)17-31(53)60-6/h21-26,28,33-35H,8-20H2,1-7H3,(H,42,51)(H,43,57)(H,44,55)(H,45,58)(H,47,52)(H,48,56)(H2,46,49,59)/t23-,24-,25-,26+,28+,33?,34?,35+/m0/s1
• InChi Key
  HZMQEZLCGJXARR-LFJGSYRESA-N
• Data Sheet Link
• MSDS Available
  Yes
• Properties
  Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6.
• Conjugation
  Biotinylated

• Gene target
  VDVAD-FMK  
• Short name
  -VDVAD-FMK
• Label
  Biotin
• Alternative name
  biotinilated-VDVAD-FMK

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