Recombinant Oryza sativa subsp. japonica Protein LSD1 (LSD1)
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Catalog number
MBS1370362
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Price
Please ask
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Size
1 mg (Yeast)
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Products_type
Recombinant Protein
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Products_short_name
[Protein LSD1 (LSD1)]
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Other_names
[protein LSD1 isoform X2; Protein LSD1; protein LSD1; Protein LESION SIMULATING DISEASE 1; OsLSD1; Putative zinc finger LSD1]
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Products_gene_name
[LSD1]
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Products_gene_name_syn
[LSD1]
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Other_gene_names
[LOC4344713; LSD1; LSD1; OsLSD1; OsJ_26122; OsLSD1]
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Purity
>85% (SDS-PAGE)
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Form
Lyophilized or liquid (Format to be determined during the manufacturing process)
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Storage_stability
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
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Gene
Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, was belonged to the superfamily of the Flavin adenine dinucleotide (FAD)-dependent amine oxidases. LSD1 specifically demethylates mono- or dimethylated dimethylated histone H3 lysine4 (H3K4) and H3 lysine 9 (H3K9) via a redox process. Recently evidences showed that LSD1 played an important role in a broad spectrum of biological processes, including cell proliferation, adipogenesis, spermatogenesis, chromosome segregation and embryonic development. Furthermore, LSD1 also could promote progress of tumor by inhibiting the tumor suppressor activity of p53. To date, as a potential drug for discovering anti-tumor drugs, the medical significance of LSD1 inhibitors have been greatly appreciated. Here, we reviewed the remarkable progress being made in understanding of LSD1, mainly on its structure, basic function and medical application in tumor therapy.
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
KDM1A
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Short name
Recombinant Oryza sativa subsp. japonica Protein LSD1 (LSD1)
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. MyBioSource advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Host
E Coli or Yeast or Baculovirus or Mammalian Cell
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Alternative name
Rec. Oryza sativa subsp. japonica Protein LSD1 (LSD1)
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Alternative technique
rec
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Gene info
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Identity
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Gene
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Long gene name
lysine demethylase 1A
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Synonyms gene
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Synonyms gene name
- amine oxidase (flavin containing) domain 2
- lysine (K)-specific demethylase 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
2004-02-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MicroRNA protein coding host genes
- Lysine demethylases
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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