HG-10-012-01

Alternative_name

[4-[[5-Chloro-4-(methylamino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-morpholinylmethanone
Description

Brain-permeable. HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2 and the G2019S mutant (IC₅₀ values are ~20.3 nM and ~ 3.2 nM, respectively). It significantly inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 µM in cells. May be a useful tool for Parkinson’s Disease research.
CAS Number

1351758-81-0
Structure Available

Y
Salt Form

No
Molecular Formula

C₁₇H₂₀ClN₅O₃
Molecular Weight

377.83
Cell Permeable

Yes
Purity

>98% by HPLC
Solubilities

DMSO (>30 mg/ml)
Handling

Protect from air and light
Tag Line

A wild-type LRRK2 and the G2019S mutant inhibitor
Storage Condition

-20 ̊C
Shipping Condition

Gel pack
Shelf Life

36 months
SMILES

O=C(N1CCOCC1)C(C=C2)=CC(OC)=C2NC3=NC=C(Cl)C(NC)=N3
InChi

InChI=1S/C17H20ClN5O3/c1-19-15-12(18)10-20-17(22-15)21-13-4-3-11(9-14(13)25-2)16(24)23-5-7-26-8-6-23/h3-4,9-10H,5-8H2,1-2H3,(H2,19,20,21,22)
InChi Key

YEVOZZZLKJKCCD-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Gene target

HG-10-012-01
Gene symbol

HCG4P1, SNORD115-10, PIRC49, SNORD116-10, IGKV2OR2-10, IGHV3OR16-10, ERVK-10
Short name

HG-10-012-01
Alternative name

HG-10-012-01

Identity

HGNC:5806
Gene

IGKV2OR2-10
Long gene name

immunoglobulin kappa variable 2/OR2-10 (pseudogene)
Synonyms gene name
- immunoglobulin kappa variable 2/OR2-10
- immunoglobulin kappa variable 2/OR2-10 pseudogene
Synonyms
- IGKV2/OR2-10
GenBank acession
- X51886
Locus

2q11.2
Discovery year

2000-04-18
Entrez gene record

28855
RefSeq identity
- NG_011661
Classification
- Immunoglobulin kappa (IGK) orphons