Anti-TNF-α (Adalimumab), humanized Antibody
-
Catalog number
A1048-100
-
Price
Please ask
-
Size
100 µg
-
-
Antibody Target
TNF-α
-
Target Alternative Name
Humira
-
Antibody Type
Monoclonal
-
Species Reactivities
Human
-
Immunogen Sequence
Recombinant human TNF a
-
Accession
NP_001019618.1
-
Gene Id
7124
-
Appearance
Colourless liquid
-
Form
Liquid
-
Concentration
2 mg/ml
-
Formulation
100 ug (2 mg/ml) of antibody in Phosphate buffered saline, pH 7.4.
-
Purification
human IgG1 was expressed in a human cell line. IgG was purified from CHO cell culture supernatant by protein A chromatography.
-
Application
Neutralization, ELISA
-
Application And Usages
Neutralization : 0.01-1 μg/ml; ELISA: 1μg/ml
-
Description
Adalimumab (Humira), a human monoclonal antibody that specifically binds to tumor necrosis factor-alpha (TNF-a). Possessing a high specificity and affinity for TNFα adalimumab exerts its therapeutic effects by blocking the interaction of TNFα with the p55 and p75 receptors as well as inducing apoptosis of TNF-expressing mononuclear cells. Adalimumab can be used for the treatment of Rhcumatoid arthritis, Juvenilc Idiopathic Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Crohn's Disease and Plaque Psoriasis.
-
Storage Condition
2°C to 8°C
-
Shipping Condition
gel pack
-
Shelf Life
12 months
-
Usage
For Research Use Only! Not to be used in humans
-
Handling
The antibody solution should be gently mixed before use
-
Western Blot Verified
Not Verified
-
Immunocytochemistry Verified
Not Verified
-
Immunofluorescence Verified
Not Verified
-
Immunoprecipitation Verified
Not Verified
-
ELISA Verified
Not Verified
-
ChIP Verified
Not Verified
-
Dot Blot Verified
Not Verified
-
Flow Cytometry Verified
Not Verified
-
-
Additional description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
-
Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
Gene
Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.
-
French translation
anticorps
-
Gene target
-
Gene symbol
TNF, TNFRSF1A, TNFRSF1B, LTBR
-
Short name
Anti-TNF-α (Adalimumab), humanized Antibody
-
Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
-
Isotype
Human IgG1
-
Alternative name
Antibody toTNF-α (Adalimumab), humanized (antibody to-)
-
Alternative technique
antibodies
-
Alternative to gene target
tumor necrosis factor, DIF and TNF-alpha and TNFA and TNFSF2, TNF and IDBG-300259 and ENSG00000232810 and 7124, transcription regulatory region DNA binding, Extracellular, Tnf and IDBG-177358 and ENSMUSG00000024401 and 21926, TNF and IDBG-634161 and ENSBTAG00000025471 and 280943
-
Gene info
-
Identity
-
Gene
-
Long gene name
tumor necrosis factor
-
Synonyms gene
-
Synonyms gene name
- tumor necrosis factor (TNF superfamily, member 2)
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year
1986-01-01
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Tumor necrosis factor superfamily
-
VEGA ID
Gene info
Gene info
Gene info
MeSH Data
-
Name
-
Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Similar products
