MYO6/Myosin VI Antibody, ALEXA FLUOR 350

• Catalog number
  bs-11264R-A350
• Price
  Please ask
• Size
  100ul

• Long name
  MYO6/Myosin VI Polyclonal Antibody, ALEXA FLUOR 350 Conjugated
• Also known as
  Anti-MYO6/Myosin VI PAb ALEXA FLUOR 350
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 350
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  MYO6/Myosin VI
• Specificity
  This is a highly specific antibody against MYO6/Myosin VI.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Myosin VI
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Myosin VI a molecular motor involved in intracellular vesicle and organelle transport, is the only Myosin motor that binds to the pointed end of Actin. This unique Myosin has only one light chain in the lever-arm domain and has highly irregular stepping with a wide range of step sizes, unlike that of other characterized Myosins. It associates with Clathrin-coated vesicles and disabled 2, indicating a role for Myosin VI in endocytosis. Mouse Myosin VI is expressed within the sensory hair cells of the cochlea. Human Myosin VI is mapped to the centromeric region of chromosome 6, a region that shows syntenic homology with the corresponding mouse chromosome 9 region, where the Snell’s Waltzer mutation is located. The behavioral effects of the mouse Snell’s Waltzer mutation are lack of responsiveness to sound, hyperactivity, head tossing and circling, due to the disorganization and fusing of stereocilia bundles within the inner ear. Defects of Myosin VI cause autosomal dominant nonsyndromic sensori-neural deafness in humans. Human Myosin VI is expressed in fetal cochlea and brain, as well as in adult brain.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  343nm/442nm
• Synonyms
  Deafness autosomal recessive 37; DFNA 22; DFNA22; DFNB 37; DFNB37; KIAA0389; MYO 6; Myo6; MYO6_HUMAN; Myosin 6; Myosin VI; Myosin-VI; Myosin6; MyosinVI; Unconventional myosin-6.
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 350
• French translation
  anticorps

• Gene target
  MYO6/Myosin  
• Gene symbol
  MYO6
• Short name
  Anti-MYO6/Myosin VI
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 350
• Alternative name
  MYO6/Myosin VI Polyclonal Antibody, ALEXA FLUOR 350
• Alternative technique
  antibodies
• Alternative to gene target
  myosin VI, DFNA22 and DFNB37, MYO6 and IDBG-93156 and ENSG00000196586 and 4646, minus-end directed microfilament motor activity, nuclei, Myo6 and IDBG-187852 and ENSMUSG00000033577 and 17920, MYO6 and IDBG-629903 and ENSBTAG00000016751 and 535127

Gene info

• Identity
  HGNC:7605
• Gene
  MYO6
• Long gene name
  myosin VI
• Synonyms gene
  • DFNA22
  • DFNB37
• Synonyms gene name
  • deafness, autosomal recessive 37
• Synonyms
  • KIAA0389
• GenBank acession
  • U90236
  • AB002387
• Locus
  6q14.1
• Discovery year
  1996-04-04
• Entrez gene record
  4646
• Pubmed identfication
  • 9259267
  • 11468689
• RefSeq identity
  • NM_004999
• Classification
  • Myosin heavy chains, class VI
• VEGA ID
  OTTHUMG00000015061
• Locus Specific Databases
  • Hereditary Hearing Loss Homepage
  • CCHMC-BMI & UC Hearing Loss Mutation Database
  • LRG_438

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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