5-Fluoroorotic Acid Monohydrate
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Catalog number
F595000
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Price
Please ask
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Size
100 mg
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Chemical available in other sizes
Please inquire size and price
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Stock availability
In Stock
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Cas number
220141-70-8
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Chemical s molecular weight
192.1
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Chemical s main applications
5-FOA has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in malarial parasites. The combination of 5-FOA and uracil has been effective in treating mice infected with Plasmodium yoelli. 5-FOA may also have potential in the treatment of human malarial infections when used in combination with other agents.
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Chemical s category
Nucleotides, Bases & Related Reagents, 5-FOA
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Other name
5-FOA
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Chemical s formula
C5H5FN2O5
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Physical properties
White to Off-White Solid
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Melting temperature
>255°C (dec.)
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Boiling temperature
No Data Available
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Chemical s soluble in
4M Aqueous Ammonium Hydroxide (Heated), DMSO (Slightly, Heated), Water (Slightly, Heated)
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Stability conditions
No Data Available
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Storage
-20°C Freezer
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