(R,R)-Hymeglusin

• Catalog number
  B1244-1000
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  (2E,4E,7R)-11-[(2R,3R)-3-(Hydroxymethyl)-4-oxooxetan-2-yl]-3,5,7-trimethylundeca-2,4-dienoic acid
• Description
  (R,R)-Hymeglusin is a specific and irreversible inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase in vitro and in vivo by covalently modifying the active Cys129 residue of the enzyme. It is a fungal beta-lactone that inhibits mevalonate biosynthesis and is a good target for statins. It displays antimicrobial and anti-fungal activity.
• CAS Number
  29066-42-0
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₈H₂₈O₅
• Molecular Weight
  324.41
• Cell Permeable
  Yes
• Purity
  ≥95% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A specific and irreversable inhibitor of HMG-CoA
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD01940046
• PubChem CID
  6440895
• PubChem CID Link
• SMILES
  CC(CCCCC1C(C(=O)O1)CO)CC(=CC(=CC(=O)O)C)C
• InChi
  InChI=1S/C18H28O5/c1-12(8-13(2)9-14(3)10-17(20)21)6-4-5-7-16-15(11-19)18(22)23-16/h9-10,12,15-16,19H,4-8,11H2,1-3H3,(H,20,21)/b13-9+,14-10+/t12-,15-,16-/m1/s1
• InChi Key
  ODCZJZWSXPVLAW-KXCGKLMDSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Hymeglusin  
• Short name
  (R R)-Hymeglusin
• Alternative name
  (R,R)-Hymeglusin

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