EPZ011989 is a potent EZH2 inhibitor with Ki values that are less than 3 nM for wild type and Tyr646 mutated EZH2. It displays 15-fold selectivity for EZH2 over EZH1 and is without effect against an array of other lysine methyltransferases. EPZ011989 demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma.
Is this a salt?
Is it cell-permeable?
≥98% by HPLC
Maximum time for storage
Protect from air and light
For cells, cell lines and tissues in culture till half confluency.
EPZ011989 for activation
EPZ011989 to measure cellular activation
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