2-Amino-N-cyclopentyl-1-(3-methoxypropyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide; CAY10591; SIRT1 activator 3; Sirtuin1 Activator 3
SirtAct is a potent Sirtuin 1 (SIRT1) activator. It increases fluorescence by 233% in a SIRT1 activity assay. SIRT1 stimulation by SirtAct leads to decreased tissue factor mediated thrombogenicity in mice. It inhibits NF-κB activation and reduces inflammatory cytokine production in lamina propria mononuclear cells from IBD patients. SirtAct also prevents and cures experimental colitis in a mouse model.
Is it cell-permeable?
≥98% by TLC
Is this a salt?
Protect from air and light
Maximum time for storage
Olive green solid
DMSO (50 mg/ml) or EtOH (20 mg/ml, warm)
For cells, cell lines and tissues in culture till half confluency.