AMBP, Alpha-1-microglobulin

• Catalog number
  AS01 014
• Price
  Please ask
• Size
  200 µl

• Available ordering format
  Lyophilized with 0.04% sodium azide
• Immunogen
  rat alpha-1-microglobulin, full length, recombinant protein, overexpressed in baculovirus-infected insect cells with N-terminal His-tag
• Raised in
  Rabbit
• Clonality
  Polyclonal
• Clone
  Polyclonal
• Purification
  Serum
• How to reconstitute
  For reconstitution add 200 µl of sterile water
• Storage condition
  store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.
• Verified applications
  Western blot (WB), radioimmunoassay (RIA), immunocytochemistry (ICC)
• Connected products
  AS01 013 | alpha-1-microglobulin (abcam BN11.10), mouse monoclonal antibodyAS13 2670 | A1M | human alpha-1-microglobulin, chicken antibodyAS10 1354 | B2M | beta-2-microglobulin, goat antibodySecondary antibodies
• Recommended dilutions for use
  1: 2000 (WB), 1: 6000 (RIA), 1: 5000 (ELISA), 1: 200 (IHC)
• Molecular weight expected аpparent
  27 kDa
• Verified reactivity
  rat
• Possible reactivity
  mouse
• No reactivity
  no confirmed exceptions from predicted reactivity known in the moment
• Supplementary information
  Contact Gentaur support center at [email protected]
• References
  Sanchez et al. (2002) Expression of the AMBP gene transcript and its two protein products, alpha(1)-microglobulin and bikunin, in mouse embryogenesis. Mech Dev, 117:293-8.Ostendorf et al. (2006) Antagonism of PDGF-D by human antibody CR002 prevents renal scarring in experimental glomerulonephritis. J Am Soc Nephrol, 17:1054-62.
• Scientific context
  Alpha-1-microglobulin is a 27-kDa glycoprotein with immunosuppressive properties. A gene AMBP in the lipocalin cluster encodes alpha-1-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the alpha-1-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins are secreted to the blood separately. Alpha-1-microglobulin is found in blood and in connective tissue in most organs. It is most abundant at interfaces between the cells of the body and the environment, such as in lungs, intestine, kidneys and placenta. Alpha 1-microglobulin is an immunomodulatory protein with a broad spectrum of possible clinical applications and seems a promising marker for evaluation of tubular function.
• Notes
  None
• Protein number
  Refer to NCBI
• TAIR number
  Refer to NCBI
• Hyperlink
• Description
  The AMBP, Alpha-1-microglobulin is a α- or alpha protein sometimes glycoprotein present in blood.

• Gene target
  AMBP   Alpha-1-microglobulin  
• Gene symbol
  AMBP, IGHVII-1-1, MIR1-1, TRUND-NNN8-1, TRUND-NNN7-1, IGKV1OR2-1, MIR101-1, MIR1289-1, MIR16-1
• Short name
  AMBP, Alpha-1-microglobulin
• Alternative name
  alpha-1-microglobulin/bikunin precursor, a-1-microglobulin
• Alternative to gene target
  alpha-1-microglobulin/bikunin precursor, A1M and EDC1 and HCP and HI30 and IATIL and ITI and ITIL and ITILC and UTI, AMBP and IDBG-81952 and ENSG00000106927 and 259, calcium oxalate binding, Extracellular, Ambp and IDBG-154074 and ENSMUSG00000028356 and 11699, AMBP and IDBG-638444 and ENSBTAG00000015676 and 280996

Gene info

• Identity
  HGNC:453
• Gene
  AMBP
• Long gene name
  alpha-1-microglobulin/bikunin precursor
• Synonyms gene
  • ITI
  • ITIL
• Synonyms
  • UTI
  • HCP
  • EDC1
  • HI30
  • IATIL
  • ITILC
• Synonyms name
  • growth-inhibiting protein 19
  • uristatin
  • complex-forming glycoprotein heterogeneous in charge
  • bikunin
  • inter-alpha-trypsin inhibitor light chain
  • protein HC
  • uronic-acid-rich protein
  • trypstatin
• GenBank acession
  • X04494
• Locus
  9q32
• Discovery year
  1986-01-01
• Entrez gene record
  259
• Pubmed identfication
  • 1708673
  • 1385302
• RefSeq identity
  • NM_001633
• Classification
  • Lipocalins
• VEGA ID
  OTTHUMG00000020534

Gene info

• Identity
  HGNC:5670
• Gene
  IGHVII-1-1
• Long gene name
  immunoglobulin heavy variable (II)-1-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable (II)-1-1
  • immunoglobulin heavy variable (II)-1-1 pseudogene
• Synonyms
  • IGHV(II)-1-1
• GenBank acession
  • AB019441
• Locus
  14q32.33
• Discovery year
  2000-04-17
• Entrez gene record
  28377
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152325

Gene info

• Identity
  HGNC:31499
• Gene
  MIR1-1
• Long gene name
  microRNA 1-1
• Synonyms gene
  • MIRN1-1
• Synonyms
  • hsa-mir-1-1
• Locus
  20q13.33
• Discovery year
  2004-04-23
• Entrez gene record
  406904
• RefSeq identity
  • NR_029780
• Classification
  • MicroRNA MIR1/206 family

Gene info

• Identity
  HGNC:50820
• Gene
  TRUND-NNN8-1
• Long gene name
  tRNA-undetermined (NNN) 8-1
• Synonyms gene name
  • transfer RNA-undetermined (NNN) 8-1
• GenBank acession
  • HG984097
• Locus
  1
• Discovery year
  2014-06-20
• Entrez gene record
  103482528
• Pubmed identfication
  • 18984615

Gene info

• Identity
  HGNC:50819
• Gene
  TRUND-NNN7-1
• Long gene name
  tRNA-undetermined (NNN) 7-1
• Synonyms gene name
  • transfer RNA-undetermined (NNN) 7-1
• GenBank acession
  • HG984096
• Locus
  1
• Discovery year
  2014-06-20
• Entrez gene record
  103482531
• Pubmed identfication
  • 18984615

Gene info

• Identity
  HGNC:5760
• Gene
  IGKV1OR2-1
• Long gene name
  immunoglobulin kappa variable 1/OR2-1 (pseudogene)
• Synonyms gene
  • IGKVPZ1
  • IGKV1OR-1
• Synonyms gene name
  • immunoglobulin kappa variable 1/OR-1
  • immunoglobulin kappa variable 1/OR-1 pseudogene
  • immunoglobulin kappa variable 1/OR-1 (pseudogene)
• Synonyms
  • IGKV1/OR-1
  • IGKV1/OR2-1
• GenBank acession
  • Z12367
• Locus
  2p11.1
• Discovery year
  2000-04-18
• Entrez gene record
  3531
• Pubmed identfication
  • 2853098
• Classification
  • Immunoglobulin kappa (IGK) orphons
• VEGA ID
  OTTHUMG00000155081

Gene info

• Identity
  HGNC:31488
• Gene
  MIR101-1
• Long gene name
  microRNA 101-1
• Synonyms gene
  • MIRN101-1
• Synonyms
  • hsa-mir-101-1
• Locus
  1p31.3
• Discovery year
  2004-04-23
• Entrez gene record
  406893
• RefSeq identity
  • NR_029516
• Classification
  • MicroRNA MIR101 family

Gene info

• Identity
  HGNC:35281
• Gene
  MIR1289-1
• Long gene name
  microRNA 1289-1
• Synonyms gene
  • MIRN1289-1
• Synonyms
  • hsa-mir-1289-1
• Locus
  20q11.22
• Discovery year
  2008-11-03
• Entrez gene record
  100302125
• RefSeq identity
  • NR_031620
• Classification
  • MicroRNA MIR1289 family

Gene info

• Identity
  HGNC:31545
• Gene
  MIR16-1
• Long gene name
  microRNA 16-1
• Synonyms gene
  • MIRN16-1
• Synonyms
  • hsa-mir-16-1
• Locus
  13q14.2
• Discovery year
  2004-04-23
• Entrez gene record
  406950
• RefSeq identity
  • NR_029486
• Classification
  • MicroRNA MIR15/16 family

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