Conjugated Primary Antibodies
Rabbit (Oryctolagus cuniculus)
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PICALM/CALM
This is a highly specific antibody against PICALM/CALM.
Clathrin assembly lymphoid myeloid leukemia; Clathrin assembly lymphoid myeloid leukemia protein; CLTH; LAP; Phosphatidylinositol-binding clathrin assembly protein; PICAL_HUMAN; PICALM.
Purified by Protein A.
Human, Mouse, Rat
Background of the antigen
Clathrin-coated pits and vesicles are assembled for receptor-mediated endocytosis through interaction with clathrin associated protein complexes. Vesicle transport is mediated from the trans-Golgi network by the adapter complex AP-1 and from the plasma membrane by the AP-2 complex. The AP-1 and AP-2 adapter protein complexes consist of clathrin binding adaptin proteins and two smaller subunits known as AP50 and AP17. The Alpha- and Beta-Adaptin chains have a similar two-domain organization with C-terminal domains that vary in both sequence and length. Alpha-Adaptin splice variants A and C display variable relative expression levels and differential distribution in different tissues. AP180 (also designated AP-3 or F1-20) is a synapse-specific clathrin assembly protein. The protein CALM (clathrin assembly protein lymphoid myeloid leukemia) is highly homologous to AP180 and may also be involved in clathrin assembly.
1ug per 1ul
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Cross-reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Alternative to gene target
phosphatidylinositol binding clathrin assembly protein, CALM and CLTH and LAP, PICALM and IDBG-66712 and ENSG00000073921 and 8301, clathrin adaptor activity, nuclei, Picalm and IDBG-198693 and ENSMUSG00000039361 and 233489, PICALM and IDBG-641926 and ENSBTAG00000001657 and 513579