A selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (IC₅₀ = 0.33 nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell differentiation and sustains self-renewal of embryonic stem (ES) cells.
Is it cell-permeable?
≥95% by HPLC
Is this a salt?
Protect from air and moisture
Maximum time for storage
DMSO (20 mg/ml) of EtOH (20 mg/ml)
For cells, cell lines and tissues in culture till half confluency.