anti-Rb (Ab 807) Antibody

• Catalog number
  79-322
• Price
  Please ask
• Size
  0.1 mg

• Gene info
  Rb operates in the midst of the cell cycle clock apparatus. Its main role is to act as a signal transducer connecting the cell cycle clock with the transcriptional machinery (Ref.1). It plays an important role in the Rb/ E2F pathway in cell proliferation, cell fate determination, and cancer (Ref.2). Cellular senescence is a stable form of cell cycle arrest that limits proliferation of damaged cells and act as a natural barrier to cancer progression. A distinct heterochromatic structure that accumulates in senescent human fibroblasts, designated as SAHF (Senescence-Associated Heterochromatic Foci). SAHF formation coincides with recruitment of heterochromatin proteins and the Rb protein to E2F-responsive promoters and is associated with the stable repression of E2F target genes. Both SAHF formation and the silencing of E2F target genes depended on the integrity of the Rb pathway and do not occur in reversibly arrested cells (Ref.3). Rb activates transcription of the c-Jun gene through the SP1-binding site within the c-Jun promoter
• Gene names
  RB, pRb, OSRC, pp110, p105-Rb, CDC2, CDC28A, CDKN1, P34CDC2, P105-RB, PP105, PP110, RB-1, RB1
• Antibodie s label
  unlabelled serum
• Purity
  Antibodies were purified by affinity-chromatography using epitope-specific peptide.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Spicific to
  This antibody detects endogenous level of total Rb protein.
• Antigen
  Rb (Ab-807) antibody was made against a peptide sequence around aa.805~809 (Y-I-S-P-L) derived from Human Rb.
• Immuno application
  Western Blot, immuno-histo-chemistry
• Antibody advice
  Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
• Suspention pH azide
  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Keep at
  Store antibody at -20 grades C for up to one year.
• Works with
  Human, Mouse, Rat
• Omim nr
  108773787
• Ncbi nr
  NP_000312.2
• KDa
  110 kDa
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  5925
• GENE symbol
  RB1
• Antigene name
  retinoblastoma 1
• Source
  Homo sapiens
• Protein nr
  P06400
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  807  
• Short name
  anti-Rb (Ab 807) Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toRb (Antibody 807) (antibody to-)
• Alternative technique
  antibodies

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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