c-erbB2 (HER-2, neu Receptor)

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Description

The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

Gene target

c-erbB2 HER-2 neu Receptor
Gene symbol

ERBB2, MIR1289-2, MIR521-2, MIR509-2, MIR512-2, MIR7-2, MIR329-2, RNU6-2, KRTAP13-2, SNORD114-2
Short name

c-erbB2 (HER-2, neu Receptor)
Alternative name

c-v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (HER-2, neu Receptor)
Alternative to gene target

v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian), CD340 and HER-2 and HER-2/neu and HER2 and MLN 19 and NEU and NGL and TKR1, ERBB2 and IDBG-46068 and ENSG00000141736 and 2064, transferase activity, nuclei, Erbb2 and IDBG-210591 and ENSMUSG00000062312 and 13866, ERBB2 and IDBG-639410 and ENSBTAG00000021798 and 505709

Identity

HGNC:3430
Gene

ERBB2
Long gene name

erb-b2 receptor tyrosine kinase 2
Synonyms gene
- NGL
Synonyms gene name
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
Synonyms
- NEU
- HER-2
- CD340
- HER2
Synonyms name
- neuro/glioblastoma derived oncogene homolog
- human epidermal growth factor receptor 2
GenBank acession
- X03363
Locus

17q12
Discovery year

2001-06-22
Entrez gene record

2064
RefSeq identity
- NM_004448
Classification
- Erb-b2 receptor tyrosine kinases
- CD molecules
- Minor histocompatibility antigens
- MicroRNA protein coding host genes
VEGA ID

OTTHUMG00000179300
Locus Specific Databases
- LRG_724