Mouse Anti-Human ZAP-70-UNLB

• Catalog number
  MBS670106
• Price
  Please ask
• Size
  25 mg

• Products_type
  Antibody
• Products_short_name
  [ZAP-70 (TCR zeta)]
• Products_name_syn
  [Mouse Anti-Human ZAP-70 - Purified, Unlabeled Antibody; Mouse Anti-Human ZAP-70 (TCR zeta)]
• Other_names
  [ZAP-70; Tyrosine-protein kinase ZAP-70; tyrosine-protein kinase ZAP-70; syk-related tyrosine kinase; 70 kDa zeta-associated protein; zeta-chain (TCR) associated protein kinase; 70 kDa zeta-associated protein; Syk-related tyrosine kinase]
• Other_gene_names
  [Zap70; Zap70; Srk; TZK; mur; 70kDa; mrtle; ZAP-70; AI327364; Srk; Zap-70]
• Clonality
  Monoclonal
• Clone
  [SBZAP]
• Reactivity
  Human
• Specificity
  Human TCR zeta ; Zap-70 (Mr 70 kDa) ZAP 70, also known as TCR zeta associated protein, is a protein tyrosine kinase (PTK) with the primary role of catalyzing the phosphorylation of tyrosine residues in cellular proteins, and thus, contributes significantly to the initiation of cell signaling. ZAP 70 is expressed on T cells and NK cells. The monoclonal antibodies SB70 and SBZAP were generated against a KLH-peptide sequence corresponding to the human ZAP 70 amino acid residues 280-309.
• Form
  Purified (UNLB) Antibody
• Storage_stability
  The purified antibody is supplied as 0.025 mg purified immunoglobulin in 0.25 mL or 0.1 mg purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or aminecontaining buffer salts added. Store at 2-8 degree C. The fluorescein (FITC) conjugate is supplied as 0.025 mg in 0.25 mL or 0.1 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C. The alkaline phosphatase (AP) conjugate is supplied as 1.0 mL of stock solution in 50mM Tris/1mM MgCl2/50% Glycerol, pH 8.0, containing 0.1% NaN3 as preservative. Store at 2-8 degree C or long-term at - 20 degree C. The horseradish peroxidase (HRP) conjugate is supplied as 1.0 mL of stock solution in 50% glycerol/50% PBS, pH 7.4. No preservative added. Store at 2-8 degree C or long-term at -20 degree C. The biotin (BIOT) conjugate is supplied as 0.025 mg in 0.25 mL or 0.1 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C. The R-phycoerythrin (R-PE) conjugate is supplied as 0.025 mg in 0.25 mL or 0.1 mg in 1.0 mL in PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze! Protect conjugated forms from light. Reagents are stable for the period shown on the label if stored as directed.
• Tested_application
  ELISA; Flow Cytometry
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Test
  MyBioSource supplies antibodies that are for research of human proteins. Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Latin name
  Mus musculus

• Gene target
  ZAP-70-UNLB  
• Gene symbol
  ZAP70, IGHV2-70, IGLVI-70, YLPM1, RNU6-70P, SWAP70, HLA-K, UCHL5, ZC3HAV1
• Short name
  Mouse Anti- ZAP-70-UNLB
• Technique
  anti-Human, anti-, Mouse, anti, antibody to, antibodies, antibodies against human proteins, mouses
• Host
  Mouse
• Isotype
  Mouse IgG1 kappa
• Species
  Human, Humans, Mouses
• Alternative name
  Mouse Antibody toHuman ZAP-70-UNLB
• Alternative technique
  murine, antibodies

Gene info

• Identity
  HGNC:12858
• Gene
  ZAP70
• Long gene name
  zeta chain of T cell receptor associated protein kinase 70
• Synonyms gene
  • SRK
• Synonyms gene name
  • SRK
• Synonyms
  • ZAP-70
  • STD
• Synonyms name
  • tyrosine-protein kinase ZAP-70
• GenBank acession
  • L05148
• Locus
  2q11.2
• Discovery year
  1995-05-16
• Entrez gene record
  7535
• Pubmed identfication
  • 1423621
• RefSeq identity
  • NM_001079
• Classification
  • SH2 domain containing
  • Syk family tyrosine kinases
• VEGA ID
  OTTHUMG00000153060
• Locus Specific Databases
  • ZAP70base: Mutation registry for autosomal recessive ZAP70 immunodeficiency
  • LRG_126

Gene info

• Identity
  HGNC:5577
• Gene
  IGHV2-70
• Long gene name
  immunoglobulin heavy variable 2-70
• GenBank acession
  • L21969
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28454
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000191972

Gene info

• Identity
  HGNC:5940
• Gene
  IGLVI-70
• Long gene name
  immunoglobulin lambda variable (I)-70 (pseudogene)
• Synonyms gene name
  • immunoglobulin lambda variable (I)-70
  • immunoglobulin lambda variable (I)-70 pseudogene
• Synonyms
  • IGLV(I)-70
• GenBank acession
  • D86993
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28763
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000150834

Gene info

• Identity
  HGNC:17798
• Gene
  YLPM1
• Long gene name
  YLP motif containing 1
• Synonyms gene
  • C14orf170
• Synonyms gene name
  • chromosome 14 open reading frame 170
• Synonyms
  • ZAP
  • PPP1R169
• Synonyms name
  • protein phosphatase 1, regulatory subunit 169
• GenBank acession
  • AK090435
• Locus
  14q24.3
• Discovery year
  2003-11-21
• Entrez gene record
  56252
• Pubmed identfication
  • 7596406
• RefSeq identity
  • NM_019589
• Classification
  • Protein phosphatase 1 regulatory subunits
• VEGA ID
  OTTHUMG00000172503

Gene info

• Identity
  HGNC:42560
• Gene
  RNU6-70P
• Long gene name
  RNA, U6 small nuclear 70, pseudogene
• Synonyms gene
  • RNU6-70
• Synonyms gene name
  • RNA, U6 small nuclear 70
• Locus
  13q12.2
• Discovery year
  2011-08-08
• Entrez gene record
  106478988

Gene info

• Identity
  HGNC:17070
• Gene
  SWAP70
• Long gene name
  switching B cell complex subunit SWAP70
• Synonyms gene name
  • SWAP switching B-cell complex 70kDa subunit
  • SWAP switching B-cell complex subunit 70
• Synonyms
  • KIAA0640
  • SWAP-70
• Synonyms name
  • switch-associated protein 70
• GenBank acession
  • AB014540
• Locus
  11p15.4
• Discovery year
  2009-05-20
• Entrez gene record
  23075
• Pubmed identfication
  • 9734811
  • 10681448
• RefSeq identity
  • NM_015055
• Classification
  • EF-hand domain containing
  • Pleckstrin homology domain containing
  • Minor histocompatibility antigens
• VEGA ID
  OTTHUMG00000165865

Gene info

• Identity
  HGNC:4969
• Gene
  HLA-K
• Long gene name
  major histocompatibility complex, class I, K (pseudogene)
• Synonyms gene
  • HLAK
  • HLA70
• Synonyms
  • HLA-70
• GenBank acession
  • M96335
• Locus
  6p22.1
• Discovery year
  1993-11-02
• Entrez gene record
  3138
• Pubmed identfication
  • 1517564
• RefSeq identity
  • NG_002398
• Classification
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031162
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:19678
• Gene
  UCHL5
• Long gene name
  ubiquitin C-terminal hydrolase L5
• Synonyms gene name
  • ubiquitin carboxyl-terminal hydrolase L5
• Synonyms
  • UCH37
  • CGI-70
  • INO80R
• Synonyms name
  • INO80 complex subunit R
• Locus
  1q31.2
• Discovery year
  2002-11-11
• Entrez gene record
  51377
• Pubmed identfication
  • 10810093
  • 16027725
• RefSeq identity
  • NM_015984
• Classification
  • Ubiquitin C-terminal hydrolases
  • INO80 complex
• VEGA ID
  OTTHUMG00000035561

Gene info

• Identity
  HGNC:23721
• Gene
  ZC3HAV1
• Long gene name
  zinc finger CCCH-type containing, antiviral 1
• Synonyms
  • ZAP
  • FLB6421
  • FLJ13288
  • MGC48898
  • ZC3HDC2
  • ZC3H2
  • PARP13
  • ARTD13
• Synonyms name
  • zinc finger antiviral protein
  • CCCH-type zinc finger antiviral protein
• GenBank acession
  • BX571742
• Locus
  7q34
• Discovery year
  2003-12-11
• Entrez gene record
  56829
• Pubmed identfication
  • 12215647
  • 12851707
  • 25635049
• RefSeq identity
  • NM_020119
• Classification
  • Poly(ADP-ribose) polymerases
  • Zinc fingers CCCH-type
• VEGA ID
  OTTHUMG00000157471

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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