LGK974

• Catalog number
  2645-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  2-(2',3-dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide
• Description
  LGK-974 is a potent and specific inhibitor of Porcupine (porcn), a Wnt-specific acyltransferase (IC₅₀ = ~0.4 nM). GK974 potently inhibits Wnt signaling, has strong efficacy in rodent tumor models, and is well-tolerated. In addition, head and neck cancer cell lines with loss-of-function mutations in the Notch signaling pathway have a high response rate to LGK974.
• CAS Number
  1243244-14-5
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₃H₂₀N₆O
• Molecular Weight
  396.44
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~ 35 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent Porcupine (porcin) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  48 months
• PubChem CID
  46926973
• PubChem CID Link
• SMILES
  CC1=C(N=CC(=C1)CC(=O)NC2=NC=C(C=C2)C3=NC=CN=C3)C4=CC(=NC=C4)C
• InChi
  InChI=1S/C23H20N6O/c1-15-9-17(12-28-23(15)18-5-6-25-16(2)10-18)11-22(30)29-21-4-3-19(13-27-21)20-14-24-7-8-26-20/h3-10,12-14H,11H2,1-2H3,(H,27,29,30)
• InChi Key
  XXYGTCZJJLTAGH-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  LGK974  
• Short name
  LGK974
• Alternative name
  LGK974

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