BAY 80-6946

• Catalog number
  B1267-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide; Copanlisib
• Description
  BAY 80-6946 is a highly selective and potent pan-class I PI3K inhibitor with sub-nanomolar IC₅₀s against PI3Kα and PI3Kδ. BAY 80-6946 displays preferential inhibition (about 10-fold) of AKT phosphorylation by PI3Kα compared with PI3Kβ in cells. Shows anticancer properties.
• CAS Number
  1032568-63-0
• Structure Available
  Yes
• Molecular Formula
  C₂₃H₂₈N₈O₄
• Molecular Weight
  480.52
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A pan-class I PI3K inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  24989044
• PubChem CID Link
• SMILES
  COC1=C(C=CC2=C1N=C(N3C2=NCC3)NC(=O)C4=CN=C(N=C4)N)OCCCN5CCOCC5
• InChi
  nChI=1S/C23H28N8O4/c1-33-19-17(35-10-2-6-30-8-11-34-12-9-30)4-3-16-18(19)28-23(31-7-5-25-20(16)31)29-21(32)15-13-26-22(24)27-14-15/h3-4,13-14H,2,5-12H2,1H3,(H2,24,26,27)(H,28,29,32)
• InChi Key
  PZBCKZWLPGJMAO-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  BAY   80-6946  
• Gene symbol
  IGHV4-80, HLA-W, RNU6-80P, VNN2, UNC80, AASDHPPT, OR4H6P
• Short name
  BAY 80-6946
• Alternative name
  BAY 80-6946

Gene info

• Identity
  HGNC:5656
• Gene
  IGHV4-80
• Long gene name
  immunoglobulin heavy variable 4-80 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable 4-80
  • immunoglobulin heavy variable 4-80 pseudogene
• GenBank acession
  • AB019437
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28390
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000191973

Gene info

• Identity
  HGNC:23425
• Gene
  HLA-W
• Long gene name
  major histocompatibility complex, class I, W (pseudogene)
• Synonyms gene
  • HLA-80
• Synonyms gene name
  • HLA-80 pseudogene
• GenBank acession
  • M96334
• Locus
  6p22.1
• Discovery year
  2004-01-16
• Entrez gene record
  352966
• Pubmed identfication
  • 10557312
  • 1517563
• RefSeq identity
  • NG_015995
• Classification
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031242
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:42570
• Gene
  RNU6-80P
• Long gene name
  RNA, U6 small nuclear 80, pseudogene
• Synonyms gene
  • RNU6-80
• Synonyms gene name
  • RNA, U6 small nuclear 80
• Locus
  13q21.33
• Discovery year
  2011-08-08
• Entrez gene record
  106478990

Gene info

• Identity
  HGNC:12706
• Gene
  VNN2
• Long gene name
  vanin 2
• Synonyms
  • FOAP-4
  • GPI-80
• Synonyms name
  • pantetheinase
• GenBank acession
  • AB026705
• Locus
  6q23.2
• Discovery year
  1998-11-13
• Entrez gene record
  8875
• Pubmed identfication
  • 9790769
  • 11491533
• Classification
  • Vanin family
• VEGA ID
  OTTHUMG00000015588

Gene info

• Identity
  HGNC:26582
• Gene
  UNC80
• Long gene name
  unc-80 homolog, NALCN channel complex subunit
• Synonyms gene
  • C2orf21
• Synonyms gene name
  • chromosome 2 open reading frame 21
  • unc-80 homolog (C. elegans)
• Synonyms
  • FLJ33496
  • KIAA1843
  • UNC-80
• GenBank acession
  • AK090815
• Locus
  2q34
• Discovery year
  2004-01-20
• Entrez gene record
  285175
• Pubmed identfication
  • 19092807
  • 19535918
  • 26708753
• RefSeq identity
  • NM_182587
• VEGA ID
  OTTHUMG00000132963

Gene info

• Identity
  HGNC:14235
• Gene
  AASDHPPT
• Long gene name
  aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
• Synonyms
  • LYS5
  • CGI-80
  • AASD-PPT
  • ACPS
• Synonyms name
  • holo ACP synthase
  • holo-[acyl-carrier-protein] synthase
• GenBank acession
  • AF302110
• Locus
  11q22.3
• Discovery year
  2000-12-21
• Entrez gene record
  60496
• Pubmed identfication
  • 12815048
  • 11286508
  • 18022563
• RefSeq identity
  • NM_015423
• VEGA ID
  OTTHUMG00000166253

Gene info

• Identity
  HGNC:8312
• Gene
  OR4H6P
• Long gene name
  olfactory receptor family 4 subfamily H member 6 pseudogene
• Synonyms gene
  • OR4H9P
  • OR4H10P
  • OR4H5P
  • OR4H11P
  • OR4H5
  • OR4H7
  • OR4H7P
  • OR4H2P
  • OR4H3P
  • OR4H11
  • OR4H2
  • OR4H3
  • OR4H1P
  • OR4H4P
  • OR4H10
  • OR4H4
  • OR4H8P
  • OR4H8
• Synonyms gene name
  • olfactory receptor, family 4, subfamily H, member 8 pseudogene
  • olfactory receptor, family 4, subfamily H, member 6 pseudogene
• Synonyms
  • OR15-71
  • OR4H6
  • OR15-82
  • OR4H9
  • OR5-39
  • OR5-84
  • OR4-114
  • OR4-115
  • OR4-119
  • OR15-69
  • OR15-80
  • OR15-81
  • OR14-58
• GenBank acession
  • U86230
• Locus
  15q11.2
• Discovery year
  1999-11-25
• Entrez gene record
  26322
• Pubmed identfication
  • 9500546
• Classification
  • Olfactory receptors, family 4
• VEGA ID
  OTTHUMG00000172787

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