p53 (FL-393) Antibody

• Catalog number
  bs-8687R
• Price
  Please ask
• Size
  0.1ml

• Long name
  p53 (FL-393) Primary Polyclonal Antibody
• Also known as
  p53 (FL-393) PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  p53 FL-393
• Specificity
  This is a highly specific antibody against p53 FL-393.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  Full length human p53 protein
• Gene ID number
  7157
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  LFS1; p53; p53 Cellular Tumor Antigen; p53 Tumor Suppressor; Phosphoprotein p53; TP53; Transformation related protein 53; TRP53; Tumor protein p53; Tumour Protein p53.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  p53   FL-393  
• Gene symbol
  PSG5, ZNF587
• Short name
  Anti-p53 FL-393
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  p53 (FL-393) Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:9522
• Gene
  PSG5
• Long gene name
  pregnancy specific beta-1-glycoprotein 5
• Synonyms
  • FL-NCA-3
  • PSG
• Synonyms name
  • pregnancy-specific beta-1 glycoprotein
  • pregnancy-specific beta 1 glycoprotein
• Locus
  19q13.31
• Discovery year
  1991-09-13
• Entrez gene record
  5673
• Pubmed identfication
  • 2735907
• RefSeq identity
  • NM_002781
• Classification
  • Pregnancy specific glycoproteins
  • V-set domain containing
• VEGA ID
  OTTHUMG00000151539

Gene info

• Identity
  HGNC:30955
• Gene
  ZNF587
• Long gene name
  zinc finger protein 587
• Synonyms
  • ZF6
  • FLJ14710
  • UBF-fl
  • FLJ20813
• GenBank acession
  • AF294842
• Locus
  19q13.43
• Discovery year
  2004-02-19
• Entrez gene record
  84914
• Pubmed identfication
  • 10520746
• RefSeq identity
  • NM_032828
• Classification
  • Zinc fingers C2H2-type
• VEGA ID
  OTTHUMG00000154901

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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