Rabbit anti Neurturin (CT) (Ligand for GFRa-2)

  • Catalog number
    X1141P
  • Price
    Please ask
  • Size
    100 μg
  • Category
    Primary Antibodies
  • Long description
    Glial cell line-derived neurotrophic factor (GDNF) plays key roles in the control of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin1,2. Physiological responses to neurturin (NTN) require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNR 3,4. The cDNAs encoding NTNR from human, rat, chicken, and mouse have been cloned recently3-8 and termed GDNFR , Ret ligand 2 (RETL2) or TGF- -related neurotrophic factor receptor 2 (TrnR2) and nominated as GFR -2 recently (9). NTN binds to and forms a complex with GFR -2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations. Neurturin and GDNF define a new family of neurotrophic factors.
  • Antibody come from
    Synthetic peptide corresponding to amino acids 178 to 193 of human neuturin.
  • Other description
    Provided in phosphate buffered saline solution containing 0.02% sodium azide as a preservative. Antigen Immunoaffiinity Purification
  • Clone
    Polyclonal
  • Antigen antibody binding interaction
    Rabbit anti Neurturin (CT) (Ligand for GFRa-2) Antibody
  • Antibody is raised in
    Rabbit
  • Antibody s reacts with
    Human
  • Antibody s reacts with these species
    This antibody doesn't cross react with other species
  • Antibody s specificity
    No Data Available
  • Application
    Western Blot
  • Antibody s suited for
    Detects neuturin by Western blot analysis at 1 µg/ml. Detects a 14 kDa band in HeLa cell lysates containing full length recombinant neuturin. Optimal concentration should be evaluated by serial dilutions.
  • Storage
    -20ºC
  • Relevant references
    1. Kotzbauer, P.T., et al. Neurturin, a relative glial-cell-line-derived neurotrophic factor. Nature 1996, 384, 467-470 _x000B__x000B_2. Heuckeroth, R.O., et al. Neurturin, a novel neurotrophic factor, is localized to mouse chromosome 17 and human chromosome 19p13.3. Genomics 1997, 44(1), 137-40_x000B__x000B_3. Klein, R.D., et al. GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. Nature 1997, 387, 717-721 _x000B__x000B_4. Buj-Bello, A., et al. Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase. Nature 1997, 387, 721-724 _x000B__x000B_5. Baloh, R.H., et al. TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. Neuron 1997, 18, 793-802 _x000B__x000B_6. Sanicola, M., et al. Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. Proc Natl Acad Sci USA 1997, 94, 6238-6243 _x000B__x000B_7. Suvanto, P., et al. Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha. Hum Mol Genet 1997, 6, 1267-1273_x000B__x000B_8. Wang, C.Y., et al. Cloning and characterization of glial cell line-derived neurotrophic factor receptor-B: a novel receptor for members of glial cell line-derived neurotrophic factor family of neurotrophic factors. Neuroscience 1998, 83(1), 7-14
  • Protein number
    see ncbi
  • Warnings
    This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
  • About
    Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
  • Latin name
    Oryctolagus cuniculus
  • Gene target
    Neurturin   Ligand   for   GFRa-2  
  • Short name
    Rabbit anti Neurturin (CT) (Ligand for GFRa-2)
  • Technique
    Rabbit, anti, antibody to
  • Host
    Rabbit, Rabbits
  • Isotype
    not specified
  • Label
    unlabeled
  • Alternative name
    production species: rabbit antibody to Neurturin (CT) (Ligand to measure GFRa-2)
  • Alternative technique
    rabbit-anti, antibodies
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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