Human CellExp™ CEACAM1/CD66a, Extracellular Domain (ED), Human Recombinant

• Catalog number
  P1245-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  Carcinoembryonic antigen-related cell adhesion molecule 1, BGP, BGP1, BGPI, CD66a, CEACAM‑1, CEACAM1, CEAM1
• Alternative_names
  Carcinoembryonic antigen-related cell adhesion molecule 1, BGP, BGP1, BGPI, CD66a, CEACAM‑1, CEACAM1, CEAM1
• Description
  Cell adhesion protein that plays role in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.
• Recombinant
  Yes
• Source
  HEK293 cells
• Purity by SDS PAGE
  ≥95%
• Assay
  SDS-PAGE
• Activity Specifications test method
  Measured by its binding ability in a functional ELISA.
• Biological activity
  Immobilized Human TIM3 at 5 ug/ml (100 ul/well) can bind to biotinylated CEACAM1 (ED) with a linear range of 0.08-10 µg/ml.
• Binding Capacity
  Immobilized Human TIM3 at 5 ug/ml (100 ul/well) can bind to biotinylated CEACAM1 (ED) with a linear range of 0.08-10 µg/ml.
• Molecular Weight
  45 kDa
• Storage Temp
  -20°C
• Shipping
  Gel Pack
• Shelf Life
  12 months
• Appearance
  Lyophilized
• Physical form description
  Lyophilized from 0.22 um filtered solution in PBS pH 7.4
• Reconstitution Instructions
  Centrifuge the vial prior to opening. Reconstitute in distilled water.
• Background Information
  CEACAM1, also known as biliary glycoprotein I (BGP I) or CD66a, is an extensively studied cell surface molecule with established functions in multiple cancer types, as well as in various compartments of the immune system. The highly glycosylated CEACAM1 contains a 35-428 amino acid extracellular domain (ECD) which includes one N-terminal V-type Ig-like domain, followed by three C2-type Ig-like domains. CEACAM1 is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic binding, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CellExp™   CEACAM1/CD66a   Extracellular   Domain  
• Gene symbol
  CEACAM1
• Short name
  CellExp™ CEACAM1/CD66a, Extracellular Domain (ED), Recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Humans
• Alternative name
  H. sapiens CellExp™ carcinoembryonic antigen-related cellular adhesion molecule 1 (biliary glycoprotein)/CD66a, Extracellular Domain (ED), H. sapiens Rec.
• Alternative technique
  rec
• Alternative to gene target
  carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein), BGP and BGP1 and BGPI, CEACAM1 and IDBG-54381 and ENSG00000079385 and 634, protein homodimerization activity, Plasma membranes

Gene info

• Identity
  HGNC:1814
• Gene
  CEACAM1
• Long gene name
  CEA cell adhesion molecule 1
• Synonyms gene
  • BGP
• Synonyms gene name
  • carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
  • carcinoembryonic antigen related cell adhesion molecule 1
• Synonyms
  • BGP1
  • CD66a
• GenBank acession
  • M72238
• Locus
  19q13.2
• Discovery year
  1989-06-30
• Entrez gene record
  634
• Pubmed identfication
  • 2457922
  • 2025273
• RefSeq identity
  • NM_001712
• Classification
  • V-set domain containing
  • CEA cell adhesion molecule family
  • CD molecules
• VEGA ID
  OTTHUMG00000151078

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Similar products