Human CellExp™ CEACAM1/CD66a, Extracellular Domain (ED), Human Recombinant
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Catalog numberP1245-1000
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PricePlease ask
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Size1 mg
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SynonymsCarcinoembryonic antigen-related cell adhesion molecule 1, BGP, BGP1, BGPI, CD66a, CEACAM‑1, CEACAM1, CEAM1
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Alternative_namesCarcinoembryonic antigen-related cell adhesion molecule 1, BGP, BGP1, BGPI, CD66a, CEACAM‑1, CEACAM1, CEAM1
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DescriptionCell adhesion protein that plays role in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.
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RecombinantYes
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SourceHEK293 cells
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Purity by SDS PAGE≥95%
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AssaySDS-PAGE
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Activity Specifications test methodMeasured by its binding ability in a functional ELISA.
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Biological activityImmobilized Human TIM3 at 5 ug/ml (100 ul/well) can bind to biotinylated CEACAM1 (ED) with a linear range of 0.08-10 µg/ml.
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Binding CapacityImmobilized Human TIM3 at 5 ug/ml (100 ul/well) can bind to biotinylated CEACAM1 (ED) with a linear range of 0.08-10 µg/ml.
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Molecular Weight45 kDa
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Storage Temp-20°C
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ShippingGel Pack
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Shelf Life12 months
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AppearanceLyophilized
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Physical form descriptionLyophilized from 0.22 um filtered solution in PBS pH 7.4
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Reconstitution InstructionsCentrifuge the vial prior to opening. Reconstitute in distilled water.
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Background InformationCEACAM1, also known as biliary glycoprotein I (BGP I) or CD66a, is an extensively studied cell surface molecule with established functions in multiple cancer types, as well as in various compartments of the immune system. The highly glycosylated CEACAM1 contains a 35-428 amino acid extracellular domain (ECD) which includes one N-terminal V-type Ig-like domain, followed by three C2-type Ig-like domains. CEACAM1 is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic binding, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolCEACAM1
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Short nameCellExp™ CEACAM1/CD66a, Extracellular Domain (ED), Recombinant
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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SpeciesHumans
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Alternative nameH. sapiens CellExp™ carcinoembryonic antigen-related cellular adhesion molecule 1 (biliary glycoprotein)/CD66a, Extracellular Domain (ED), H. sapiens Rec.
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Alternative techniquerec
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Alternative to gene targetcarcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein), BGP and BGP1 and BGPI, CEACAM1 and IDBG-54381 and ENSG00000079385 and 634, protein homodimerization activity, Plasma membranes
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Gene info
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Identity
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Gene
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Long gene nameCEA cell adhesion molecule 1
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Synonyms gene
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Synonyms gene name
- carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
- carcinoembryonic antigen related cell adhesion molecule 1
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Synonyms
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GenBank acession
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Locus
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Discovery year1989-06-30
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- V-set domain containing
- CEA cell adhesion molecule family
- CD molecules
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data