Rb2 p130 Antibody

  • Catalog number
    PA1895
  • Price
    Please ask
  • Size
    0,1 mg
  • Target antigen
    Rb2 p130
  • Clonality
    Polyclonal antibody
  • Clone
    Polyclonal antibody
  • Raised in
    rabbit
  • Type of the antibody
    IgG polyclonal antibody
  • Product form
    freeze-dried
  • Reacts with species
    human Predicted to work with: mouse, rat
  • Analyses
    WB
  • Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human Rb2 p130(1120-1139aa ENHSALLRRLQDVANDRGSH), identical to the related rat sequence and different from the related mouse sequence by one amino acid.
  • Product configuration
    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
  • Purification
    Immunogen affinity purified.
  • Solubilization
    The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
  • Storage condtions
    Keep the Rb2 p130 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
  • Tips
    The Rb2 p130 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
  • Background
    RBL2(Retinoblastoma-like protein 2) is a protein that in humans is encoded by the RBL2 gene. It is also known as Retionblastoma-related gene(RB2), P130. Yeung et al.(1993) mapped the RBL2 gene to human chromosome 16q12.2 and rat chromosome 19, using fluorescence in situ hybridization and somatic hybrid cell analysis, respectively. Based on known syntenic relationships among human, rat and mouse, the data suggested that the mouse homolog resides on chromosome 8. Deletions of chromosome 16q have been found in several human neoplasms, including breast, ovarian, hepatic, and prostate cancers, which supports the involvement of RB2 in human cancer as a tumor suppressor gene. Kong et al.(2006)found that RBL2 and RINT1 were essential for telomere length control in human fibroblasts, with loss of either protein leading to longer telomeres. Williams et al.(2006)found that mouse fibroblasts lacking Rb were less susceptible to an oncogenic HRAS allele than wildtype cells. In contrast, p107(RBL1;) -/- and p130 -/- fibroblasts were more susceptible to HRAS-mediated transformation than wildtype cells.
  • Related articles
    1. Kong, L.-J., Meloni, A. R., Nevins, J. R.The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1.Molec. Cell 22: 63-71, 2006. 2. Williams, J. P., Stewart, T., Li, B., Mulloy, R., Dimova, D., Classon, M.The retinoblastoma protein is required for Ras-induced oncogenic transformation.Molec. Cell. Biol. 26: 1170-1182, 2006. 3. Yeung, R. S., Bell, D. W., Testa, J. R., Mayol, X., Baldi, A., Grana, X., Klinga-Levan, K., Knudson, A. G., Giordano, A.The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19.Oncogene 8: 3465-3468, 1993.
  • Gene Name
    RBL2
  • Protein Name
    Retinoblastoma-like protein 2
  • Gene Full Name
    retinoblastoma-like 2(p130)
  • Synonyms
    130 kDa retinoblastoma associated protein antibody|FLJ26459 antibody|p130 antibody|PRB 2 antibody|PRB2 antibody|Rb 2 antibody|Rb2 antibody|RBL 2 antibody|RBL2 antibody|RBR 2 antibody|RBR2 antibody|Retinoblastoma like 2 antibody|Retinoblastoma like protein 2 antibody|Retinoblastoma related gene antibody
  • Uniprot ID
    Q08999
  • Properties
    If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
    Rb2   p130  
  • Gene symbol
    RBL2
  • Short name
    Rb2 p130 Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Alternative name
    Rb2 p130 (antibody to-)
  • Alternative technique
    antibodies
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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