Recombinant Human ACP1 / LMW-PTP Protein (GST tag)

• Catalog number
  PKSH031337-20µg
• Price
  Please ask
• Size
  20µg

• Synonym
  HAAP
• Activity
  Measured by its ability to cleave a substrate, pNitrophenyl phosphate (pNPP). The specific activity is >65,000 pmol/min/μg.
• Sequence
  Met 1-His 158
• Fusion tag
  N-GST
• Accession
  AAI06012.1
• Expressed Host
  E. coli
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞88 % as determined by SDS-PAGE
• Endotoxin
  Please contact us for more information.
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  44.3 kDa
• AP Mol Mass
  40 kDa
• Formulation
  Lyophilized from sterile 50mM Tris, 150mM NaCl, pH 8.0
• Background
  The low molecular weight phosphotyrosine phosphatase (LMW-PTP), also known as Acid phosphatase 1 (ACP1), belongs to the low molecular weight phosphotyrosine protein phosphatase family are involved in the regulation of important physiological functions, including stress resistance and synthesis of the polysaccharide capsule. ACP1/LMW-PTP is an enzyme involved in platelet-derived growth factor-induced mitogenesis and cytoskeleton rearrangement. LMW-PTP is able to specifically bind and dephosphorylate activated PDGF receptor, thus modulating PDGF-induced mitogenesis. In vitro, LMW-PTP was found to efficiently dephosphorylate activated FcgammaRIIA and LAT, but not Syk or phospholipase Cgamma2. The overexpression of LMW-PTP inhibited activation of Syk downstream of FcgammaRIIA and reduced intracellular Ca(2+) mobilization. It been demonstrated that LMW-PTP is responsible for FcgammaRIIA dephosphorylation, and is implicated in the down-regulation of cell activation mediated by this ITAM-bearing immunoreceptor. In addition, ACP1 is a highly polymorphic phosphatase that is especially abundant in the central nervous system and is known to be involved in several signal transduction pathways.
• Technical data
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  ACP1   LMW-PTP   Protein   GST   tag  
• Gene symbol
  ACP1, PTPN13, MGST3, PTPRK, NDUFAB1, PTPRO, PTPRR, REG1A, PTPN7, PTPN12
• Short name
  Recombinant ACP1 / LMW-PTP Protein (GST tag)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  tag
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens ACP1 / LMW-PTP Protein (GST detection labelled)
• Alternative technique
  rec

Gene info

• Identity
  HGNC:122
• Gene
  ACP1
• Long gene name
  acid phosphatase 1
• Synonyms gene name
  • acid phosphatase 1, soluble
• Synonyms
  • HAAP
  • LMW-PTP
  • LMWPTP
• Synonyms name
  • acid phosphatase of erythrocyte
  • low molecular weight phosphotyrosine protein phosphatase
  • red cell acid phosphatase
• GenBank acession
  • M87546
• Locus
  2p25.3
• Discovery year
  1986-01-01
• Entrez gene record
  52
• Pubmed identfication
  • 457131
  • 1587862
  • 8586411
• RefSeq identity
  • NM_004300
• Classification
  • Acid phosphatases
  • Class II Cys-based phosphatases
• VEGA ID
  OTTHUMG00000086933

Gene info

• Identity
  HGNC:9646
• Gene
  PTPN13
• Long gene name
  protein tyrosine phosphatase non-receptor type 13
• Synonyms gene name
  • protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
• Synonyms
  • PTP1E
  • PTP-BAS
  • PTPL1
  • PTP-BL
• Synonyms name
  • APO-1/CD95 (Fas)-associated phosphatase
• Locus
  4q21.3
• Discovery year
  1995-02-17
• Pubmed identfication
  • 8287977
• Classification
  • Protein tyrosine phosphatases non-receptor type
  • PDZ domain containing
  • FERM domain containing
• VEGA ID
  OTTHUMG00000160968

Gene info

• Identity
  HGNC:7064
• Gene
  MGST3
• Long gene name
  microsomal glutathione S-transferase 3
• Synonyms
  • GST-III
• Synonyms name
  • microsomal glutathione S-transferase III
  • microsomal GST-3
  • microsomal GST-III
• GenBank acession
  • AF026977
• Locus
  1q24.1
• Discovery year
  1997-10-16
• Entrez gene record
  4259
• Pubmed identfication
  • 9278457
• RefSeq identity
  • NM_004528
• Classification
  • Microsomal glutathione S-transferases
• VEGA ID
  OTTHUMG00000034627

Gene info

• Identity
  HGNC:9674
• Gene
  PTPRK
• Long gene name
  protein tyrosine phosphatase receptor type K
• Synonyms
  • R-PTP-kappa
• GenBank acession
  • L77886
• Locus
  6q22.33
• Discovery year
  1998-02-09
• Entrez gene record
  5796
• Pubmed identfication
  • 9047348
  • 8663237
• Classification
  • Protein tyrosine phosphatases receptor type
  • Fibronectin type III domain containing
  • Immunoglobulin like domain containing
• VEGA ID
  OTTHUMG00000015536

Gene info

• Identity
  HGNC:7694
• Gene
  NDUFAB1
• Long gene name
  NADH:ubiquinone oxidoreductase subunit AB1
• Synonyms gene name
  • NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 (8kD, SDAP)
  • NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
• Synonyms
  • SDAP
  • FASN2A
  • ACP
  • ACP1
• Synonyms name
  • acyl carrier protein, mitochondrial
  • complex I SDAP subunit
• GenBank acession
  • AF087660
• Locus
  16p12.2
• Discovery year
  1997-12-17
• Entrez gene record
  4706
• Pubmed identfication
  • 9763677
  • 9878551
• RefSeq identity
  • NM_005003
• Classification
  • NADH:ubiquinone oxidoreductase supernumerary subunits
• VEGA ID
  OTTHUMG00000096985

Gene info

• Identity
  HGNC:9678
• Gene
  PTPRO
• Long gene name
  protein tyrosine phosphatase receptor type O
• Synonyms
  • PTPU2
  • GLEPP1
  • PTP-U2
  • PTP-oc
  • NPHS6
• Synonyms name
  • osteoclastic transmembrane protein-tyrosine phosphatase
• GenBank acession
  • U20489
• Locus
  12p12.3
• Discovery year
  1995-02-22
• Entrez gene record
  5800
• Pubmed identfication
  • 7519601
  • 7665166
  • 21722858
• Classification
  • Protein tyrosine phosphatases receptor type
  • Fibronectin type III domain containing
• VEGA ID
  OTTHUMG00000168786

Gene info

• Identity
  HGNC:9680
• Gene
  PTPRR
• Long gene name
  protein tyrosine phosphatase receptor type R
• Synonyms gene
  • PTPRQ
• Synonyms
  • PTPBR7
  • PTP-SL
  • EC-PTP
  • PCPTP1
• GenBank acession
  • D64053
• Locus
  12q15
• Discovery year
  1999-10-28
• Entrez gene record
  5801
• Pubmed identfication
  • 7557444
  • 10393441
• RefSeq identity
  • NM_002849
• Classification
  • Protein tyrosine phosphatases receptor type
• VEGA ID
  OTTHUMG00000169502

Gene info

• Identity
  HGNC:9951
• Gene
  REG1A
• Long gene name
  regenerating family member 1 alpha
• Synonyms gene
  • REG
• Synonyms gene name
  • regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)
• Synonyms
  • PSP
  • PTP
  • PSPS
  • PSPS1
• Synonyms name
  • pancreatic stone protein
  • pancreatic thread protein
• Locus
  2p12
• Discovery year
  1992-06-05
• Entrez gene record
  5967
• Pubmed identfication
  • 2332435
  • 8333731
• RefSeq identity
  • NM_002909
• Classification
  • C-type lectin domain containing
• VEGA ID
  OTTHUMG00000130016

Gene info

• Identity
  HGNC:9659
• Gene
  PTPN7
• Long gene name
  protein tyrosine phosphatase non-receptor type 7
• Synonyms
  • HEPTP
  • LC-PTP
• GenBank acession
  • BC001746
• Locus
  1q32.1
• Discovery year
  1993-03-03
• Entrez gene record
  5778
• Pubmed identfication
  • 1510684
• RefSeq identity
  • NM_002832
• Classification
  • Protein tyrosine phosphatases non-receptor type
• VEGA ID
  OTTHUMG00000035931

Gene info

• Identity
  HGNC:9645
• Gene
  PTPN12
• Long gene name
  protein tyrosine phosphatase non-receptor type 12
• Synonyms
  • PTPG1
  • PTP-PEST
• Locus
  7q11.23
• Discovery year
  1993-03-03
• Pubmed identfication
  • 7509295
• Classification
  • Protein tyrosine phosphatases non-receptor type
• VEGA ID
  OTTHUMG00000023501

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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