MSH3 Antibody

• Catalog number
  R31698
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  MSH3
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the MSH3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This MSH3 antibodyis to be used only for research purposes and not for diagnostics..
• Gene ID
  4437
• Purity
  Antigen affinity
• Description
  MutS homolog 3 (MSH3), also known as MRP1 or DUP, is a human homologue of the bacterial mismatch repair protein MutS that participates in the mismatch repair (MMR) system. It is mapped to 5q14.1. The primary function of MSH3 is to maintain the stability of the genome and enact tumor suppression by forming the heterodimer MutSb to correct long insertion/deletion loops and base-base mispairs. The most significant role of MSH3 in cancer is the suppression of tumors by repair of somatic mutations in DNA that occur as the result of base-base mispairs and insertion/deletion loops. Both loss of expression and over expression of the protein can leader tocarcinogenic effects. Additionally, it has been shown that inactivation of the gene may be involved in the development of hematologic malignancies.
• Immunogen
  Human partial recombinant protein (AA 434-739) was used as the immunogen for this MSH3 antibody.
• Storage
  After reconstitution, the MSH3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MSH3  
• Gene symbol
  MSH3
• Short name
  Anti-MSH3
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to MSH3
• Alternative technique
  antibodies
• Alternative to gene target
  mutS homolog 3 (E. coli), DUP and MRP1, MSH3 and IDBG-31502 and ENSG00000113318 and 4437, oxidized purine DNA binding, nuclei, Msh3 and IDBG-171801 and ENSMUSG00000014850 and 17686, MSH3 and IDBG-646483 and ENSBTAG00000007684 and 616744

Gene info

• Identity
  HGNC:7326
• Gene
  MSH3
• Long gene name
  mutS homolog 3
• Synonyms gene name
  • mutS (E. coli) homolog 3
  • mutS homolog 3 (E. coli)
• Synonyms
  • DUP
  • MRP1
• Synonyms name
  • Divergent upstream protein
  • Mismatch repair protein 1
• GenBank acession
  • U61981
• Locus
  5q14.1
• Discovery year
  1995-09-28
• Entrez gene record
  4437
• RefSeq identity
  • NM_002439
• Classification
  • MutS homologs
• VEGA ID
  OTTHUMG00000162540

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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