Human CellExp™ CD244 / 2B4 / SLAMF4, human recombinant

  • Catalog number
    7374-50
  • Price
    Please ask
  • Size
    50 ug
  • Synonyms
    CD244, 2B4, SLAMF4, NKR2B4, NAIL, h2B4
  • Alternative_names
    CD244, 2B4, SLAMF4, NKR2B4, NAIL, h2B4
  • Description
    Modulates receptor-ligand interactions to enhance leukocyte activation
  • Recombinant
    Yes
  • Source
    HEK293 cells
  • Purity by SDS PAGE
    ≥95%
  • Assay
    SDS-PAGE
  • Biological activity
    Measured by its binding ability in a functional ELISA. Immobilized rh CD244 / 2B4 at 2 ug/ml (100 ul/well) can bind human CD48. The EC50 of human CD48 is 0.39 ug/ml.
  • Results
    Measured by its binding ability in a functional ELISA. Immobilized rh CD244 / 2B4 at 2 ug/ml (100 ul/well) can bind human CD48. The EC50 of human CD48 is 0.39 ug/ml.
  • Molecular Weight
    This protein is fused with polyhistidine tag at the C-terminus, and has a calculated MW of 23.1 kDa. The predicted N-terminus is Cys 22. DTT-reduced Protein migrates as 40-50 kDa due to glycosylation.
  • Storage Temp
    -20°C
  • Shipping
    Gel Pack
  • Shelf Life
    12 months
  • Appearance
    Lyophilized
  • Physical form description
    Lyophilized from 0.22 um filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
  • Reconstitution Instructions
    Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
  • Background Information
    Natural killer cell receptor 2B4 is also known as NK cell type I receptor protein 2B4 (NKR2B4 or h2B4), SLAM family member 4 (SLAMF4), Signaling lymphocytic activation molecule 4, CD antigen CD244. NKR2B4 / CD244 contain two Ig-like (immunoglobulin-like) domains. CD244 is expressed in spleen, PBL, followed by lung, liver, testis and small intestine. CD244 interacts with CD48. Following phosphorylation, CD244 is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. SLAMF4 modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family.
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
    CellExp™   CD244   2B4   SLAMF4  
  • Gene symbol
    CD244, GSTT1-AS1
  • Short name
    CellExp™ CD244 / 2B4 / SLAMF4, recombinant
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Species
    Humans
  • Alternative name
    H. sapiens CellExp™ CD244 molecule, natural killer cellular receptor 2B4 / 2B4 / SLAMF4, H. sapiens Rec.
  • Alternative technique
    rec
  • Alternative to gene target
    CD244 molecule, natural killer cell receptor 2B4, CD244 and IDBG-104114 and ENSG00000122223 and 51744, protein binding, Cell surfaces, Cd244 and IDBG-204694 and ENSMUSG00000004709 and 18106, CD244 and IDBG-630400 and ENSBTAG00000002951 and 513468
Gene info
  • Identity
  • Gene
  • Long gene name
    CD244 molecule
  • Synonyms gene name
    • natural killer cell receptor 2B4
    • CD244 natural killer cell receptor 2B4
    • CD244 molecule, natural killer cell receptor 2B4
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2003-10-23
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Ig-like cell adhesion molecule family
    • Immunoglobulin like domain containing
    • CD molecules
  • VEGA ID
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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