Target of this antibody:
The caspase family of cysteine proteases plays a key role in apoptosis. Caspase-7, also known as Mch3α, ICE/LAP3 and CMH1, is a 34 kDa protein that is activated during Fas- and TNF-induced apoptosis. Caspase-7 has been identified as a major contributor to the execution phase of cellular apoptosis. It cleaves essential cellular machinery following its own cleavage from an inactive proenzyme to an active heterodimeric form. Caspase-7 is processed by caspase-3, -6, -8, -9, and –10 as well as by Granzyme B.
Clonality of antibody:
Synthetic peptide from human caspase-7.
Concentration of antibody:
Formulation of this antibody:
100 µg (0.5 µg/ml) in PBS containing 1 mg/ml BSA and 1.5 mM thimerosal and 50% glycerol
This antibody has been succesfully tested for use in following methods:
Western blot, Immunoprecipitation
Western blot analysis (0.5-2 µg/ml) and immunoprecipitation (4-10 µg/ml). However the optimal conditions should be determined individually. Detects both pro-caspase-7 (34 kDa) and the large subunit of cleaved caspase-7 (19 kDa) in apoptosis cells on SDS-PAGE immunoblots.
anti-Caspase-7 Antibody (Clone B4-G2)
antibody to-caspase-7 (Antibody to) (clonality B4-G2)
Long gene name small NF90 (ILF3) associated RNA G2
Synonyms gene name
- small ILF3/NF90-associated RNA G2
Discovery year 2008-07-03
Entrez gene record 100170228
- Small NF90 (ILF3) associated RNAs