FOXP3 Antibody

• Catalog number
  RP1032
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  FOXP3
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human
• Analyses
  IHC-P
• Immunogen
  E.coli-derived human FOXP3 recombinant protein (Position: H101-P431). Human FOXP3 shares 88% amino acid (aa) sequence identity with mouse FOXP3.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the FOXP3 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The FOXP3 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  FOXP3(forkhead box P3) is a protein involved in immune system responses. The human FOXP3 genes contain 11 coding exons. Exon-intron boundaries are identical across the coding regions of the mouse and human genes. By genomic sequence analysis, the FOXP3 gene maps to the p arm of the X chromosome(specifically, Xp11.23). A member of the FOX protein family, FOXP3 appears to function as a master regulator in the development and function of regulatory T cells. While the precise control mechanism has not yet been established, FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription.
• Related articles
  1. Allan, S. E., Passerini, L., Bacchetta, R., Crellin, N., Dai, M., Orban, P. C., Ziegler, S. F., Roncarolo, M. G., Levings, M. K.The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.J. Clin. Invest. 115: 3276-3284, 2005. 2. Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M. E., Ferguson, P. J., Whitesell, L., Kelly, T. E., Saulsbury, F. T., Chance, P. F., Ochs, H. D.The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.Nature Genet. 27: 20-21, 2001. 3. Hong, J., Li, N., Zhang, X., Zheng, B., Zhang, J. Z.Induction of CD4+CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3.Proc. Nat. Acad. Sci. 102: 6449-6454, 2005.
• Gene Name
  FOXP3
• Protein Name
  Forkhead box protein P3
• Gene Full Name
  forkhead box P3
• Synonyms
  AIID antibody|DIETER antibody|Forkhead box P3 antibody|Forkhead box protein P3 antibody|foxp3 antibody|FOXP3_HUMAN antibody|FOXP3delta7 antibody|Immune dysregulation polyendocrinopathy enteropathy X linked antibody|Immunodeficiency polyendocrinopathy enteropathy X linked antibody|IPEX antibody|JM2 antibody|MGC141961 antibody|MGC141963 antibody|OTTHUMP00000025832 antibody|OTTHUMP00000025833 antibody|OTTHUMP00000226737 antibody|PIDX antibody|SCURFIN antibody|XPID antibody
• Uniprot ID
  Q9BZS1
• Entrez GeneID
  50943
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Gene
  Forkhead Box Protein P3 scurfin FOXP3, is a protein involved in immune system responses. A member of the FOX protein family, FOXP3 appears to function as a master regulator of the regulatory pathway in the development and function of regulatory T cells. Foxp3 or forkhead box P3 or skurfin or scurfin or skurfina is also known as IPEX, AIID, PIDX, XPID and DIETER.
• French translation
  anticorps

• Gene target
  FOXP3  
• Gene symbol
  FOXP3
• Short name
  FOXP3 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  forkhead box P3 (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  forkhead box P3, FOXP3 and IDBG-66215 and ENSG00000049768 and 50943, NFAT protein binding, nuclei, Foxp3 and IDBG-128986 and ENSMUSG00000039521 and 20371, FOXP3 and IDBG-637186 and ENSBTAG00000013279 and 506053

Gene info

• Identity
  HGNC:6106
• Gene
  FOXP3
• Long gene name
  forkhead box P3
• Synonyms gene
  • IPEX
• Synonyms gene name
  • immune dysregulation, polyendocrinopathy, enteropathy, X-linked
• Synonyms
  • JM2
  • XPID
  • AIID
  • PIDX
  • DIETER
  • SCURFIN
• Locus
  Xp11.23
• Discovery year
  2000-05-05
• Entrez gene record
  50943
• Pubmed identfication
  • 10677306
  • 11138001
• RefSeq identity
  • NM_014009
• Classification
  • Forkhead boxes
• VEGA ID
  OTTHUMG00000024135
• Locus Specific Databases
  • FOXP3base: Mutation registry for Immunodysregulation, polyendocrinopathy, and enteropathy, X-linked; IPEX
  • Global Variome shared LOVD
  • LRG_62

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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