Human CellExp™ IL17R /CD217, human recombinant

• Catalog number
  7430-50
• Price
  Please ask
• Size
  50 ug

• Synonyms
  CD217, CDw217, IL-17RA, IL17R, CANDF5, hIL-17R
• Alternative_names
  CD217, CDw217, IL-17RA, IL17R, CANDF5, hIL-17R
• Recombinant
  Yes
• Source
  HEK293 cells
• Purity by SDS PAGE
  ≥98%
• Assay
  SDS-PAGE
• Biological activity
  Measured by its ability to inhibit IL-17 induced IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. The ED50 for this effect is typically 0.01-0.1 µg/mL in the presence of 10 ng/mL recombinant human IL-17.
• Results
  Measured by its ability to inhibit IL-17 induced IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. The ED50 for this effect is typically 0.01-0.1 µg/mL in the presence of 10 ng/mL recombinant human IL-17.
• Molecular Weight
  This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 34.3 kDa. The predicted N-terminus is Leu 33. DTT-reduced Protein migrates as 55-60 kDa due to glycosylation.
• Storage Temp
  -20°C
• Shipping
  Gel Pack
• Shelf Life
  12 months
• Appearance
  Lyophilized
• Physical form description
  Lyophilized from 0.22 um filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
• Reconstitution Instructions
  Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
• Background Information
  Interleukin 17 receptor A (IL17RA), also known as cluster of differentiation w217 (CDw217), is a pro-inflammatory cytokine secreted by activated T-lymphocytes, belong to ubiquitous type I membrane glycoprotein, and binds with low affinity to interleukin 17A (IL17A). IL 17R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. IL 17RA associates with IL 17RC to form a signaling receptor complex for IL17 and IL17F. Ligand and IL 17RA ligation promotes T cell activation and the production of IL - 6, G-CSF, SCF, and multiple pro-inflammatory chemokines. Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5).
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CellExp™   IL17R   CD217  
• Gene symbol
  IL17RA
• Short name
  CellExp™ IL17R /CD217, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Humans
• Alternative name
  H. sapiens CellExp™ IL17R /CD217, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:5985
• Gene
  IL17RA
• Long gene name
  interleukin 17 receptor A
• Synonyms gene
  • IL17R
• Synonyms gene name
  • interleukin 17 receptor
• Synonyms
  • hIL-17R
  • IL-17RA
  • CDw217
  • CD217
• GenBank acession
  • U58917
• Locus
  22q11.1
• Discovery year
  1999-10-29
• Entrez gene record
  23765
• Pubmed identfication
  • 9367539
  • 10591208
• RefSeq identity
  • NM_014339
• Classification
  • Interleukin receptors
  • CD molecules
• VEGA ID
  OTTHUMG00000150026
• Locus Specific Databases
  • LRG_355

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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