Heptelidic Acid

• Catalog number
  2215-1000
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  Koningic acid; Avocettin; FO-4443; BRN 5091359
• Description
  A sesquiterpene antibiotic, isolated from Trichoderma sp. A potent and selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor. Binds to the essential Cys149 residue in the catalytic site of GAPDH. Selectively kills high-glycolytic cancer cells through glucose-dependent active ATP deprivation. Selective and competitive inhibitor of mammalian DNA polymerases beta, lambda and terminal deoxynucleotidyl transferase (TdT) in family X of pols.
• CAS Number
  74310-84-2
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₅H₂₀O₅
• Molecular Weight
  280.32
• Cell Permeable
  Yes
• Purity
  ³95% by HPLC
• Solubilities
  DMSO or EtOH
• Handling
  Protect from air and light
• Tag Line
  A potent and selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24months
• PubChem CID
  124361
• PubChem CID Link
• SMILES
  CC(C)C1CCC2(CO2)C3C1C=C(COC3=O)C(=O)O
• InChi
  InChI=1S/C15H20O5/c1-8(2)10-3-4-15(7-20-15)12-11(10)5-9(13(16)17)6-19-14(12)18/h5,8,10-12H,3-4,6-7H2,1-2H3,(H,16,17)/t10?,11-,12-,15-/m1/s1
• InChi Key
  JESMSCGUTIEROV-NOFREYILSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Heptelidic   Acid  
• Short name
  Heptelidic Acid
• Alternative name
  Heptelidic Acid

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