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DNMT1 Antibody Biotin

DNMT1 Antibody Biotin is available 3 times from Stressmarq labs

SMC-231D-BI | DNMT1 Antibody: Biotin size: 100 µg | 546.21 USD

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SMC-200D-BI | DNMT1 Antibody: Biotin size: 100 µg | 556.49 USD

Catalog number SMC-200D-BI
Supplier StressMarq
Price556.49 USD
Size 100 µg
Alternative Name DNMT1 Antibody, Clone 60B1220.1: Biotin
Other name Mouse Anti-Human DNMT1 Monoclonal IgG1 Kappa
Clone Number 60B1220.1
Immunogen Raised against a synthetic peptide corresponding to amino acids 637-650 of human DNMT1
Applications WB , IHC , IP , ChIP
Species Reactivity Human , Mouse , Fish , Zebrafish (Danio rerio)
Storage Buffer PBS, 0.05% BSA, 0.05% sodium azide
Storage Temperature 4°C
1. Gene info
Identity2976
GeneDNMT1
Long gene name DNA methyltransferase 1
Synonyms gene
Synonyms gene name
  • DNA (cytosine-5-)-methyltransferase 1
Synonyms
GenBank acession
Locus19p13.2
Discovery year 1991-06-04
Entrez gene record1786
Pubmed identfication
RefSeq identity
Classification
  • Zinc fingers CXXC-type
  • Seven-beta-strand methyltransferase motif containing
Havana BLAST/BLATOTTHUMG00000180397
Locus Specific Databases
2. Gene info
Identity2975
GeneDNMT
Long gene name DNA methyltransferase 1
Synonyms gene name
  • DNA (cytosine-5-)-methyltransferase 1
GenBank acession
Locus19p13.2
Discovery year 1991-06-04
Entrez gene record1786
Pubmed identfication
RefSeq identity
Classification
  • Zinc fingers CXXC-type
  • Seven-beta-strand methyltransferase motif containing
Havana BLAST/BLATOTTHUMG00000180397
Locus Specific Databases
MeSH Data
Concept
Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
Additional information
PubMedThese findings identify functional cross-talk between KIT and DNMT1 in the development of drug resistance, implying the reciprocal targeting of protein kinases and DNA methyltransferases as an essential strategy for durable responses in lung cancer.
The inhibition of DNMT1 contributed to the activation of p53 pathways.
Unlike Dnmt1, pre-existing cytosine methylation at CpG sites or non-CpG sites does not stimulate Dnmt3a activity in vitro and in vivo.
DNMT1 expression was correlated to the methylation of RASSF1A, tumor grade and stage, which implied that DNMT1 may contribute to the carcinogenesis and development of adenoid cystic carcinoma.
Different binding properties and function of CXXC zinc finger domains in Dnmt1 and Tet1.
mammalian DNMT1, DNMT3B, and, to a much less extent, DNMT3A, can also act in vitro as DNA demethylases in a Ca2+ ion- and redox state-dependent manner
Data indicate that salivary gland epithelial cells (SGEC) demethylation in Sjogren's syndrome (SS)patients was associated with a 7-fold decrease in DNA methyl transferase DNMT1 and a 2-fold increase in Gadd45-alpha expression.
Hypermethylated E2F transcription factor 1 (E2F1) motif is a key regulatory element for the DNMT1 gene in BRCA1-mutated breast cancer
There appeared to be a reciprocal regulatory relationship of miR-152/DNMT1 expression, as cells treated with siRNA DNMT1 caused miR-152 to be re-expressed in all cell lines.
in HCT116 colorectal cancer cells lacking DNA methyltransferases DNMT1 or DNMT3B, LCT13 expression decreases, while cells lacking both DNMTs or treated with the DNMT inhibitor 5-azacytidine (5-aza) show no change in LCT13 expression.

SMC-201D-BI | DNMT1 Antibody: Biotin size: 100 µg | 556.49 USD

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Conjugate Biotin
Category Antibodies
Host Species Mouse
Immunogen Species Human
Swiss-Prot P26358
Concentration 1 mg/ml
Target DNMT1
Specificity Detects ~180kDa. It will cross-react with mouse DNMT1.
Shipping Temperature Blue Ice or 4°C
Product Type Monoclonal
Gene ID 1786
Properties If you buy Antibodies supplied by StressMarq they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6.
Conjugation Biotinylated
French translation anticorps
Gene targetDNMT1
Short name DNMT1 Antibody:
Technique Antibody
Label Biotin
Alternative name DNMT1 (Antibody to): biotinilated
Alternative technique antibodies
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