Human CellExp™ CD319 / SLAMF7 / CRACC, human recombinant

• Catalog number
  7376-50
• Price
  Please ask
• Size
  50 ug

• Synonyms
  SLAMF7, CD319, CS1, CRACC, 19A, FOAP-12
• Alternative_names
  SLAMF7, CD319, CS1, CRACC, 19A, FOAP-12
• Description
  Mediates NK cell activation
• Recombinant
  Yes
• Source
  HEK293 cells
• Purity by SDS PAGE
  ≥95%
• Assay
  SDS-PAGE
• Biological activity
  Measured by its ability to bind biotinylated human SLAMF7 in a functional ELISA.
• Results
  Measured by its ability to bind biotinylated human SLAMF7 in a functional ELISA.
• Molecular Weight
  This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 23.2 kDa. The predicted N-terminus is Ser 23. DTT-reduced Protein migrates as 33-48 kDa due to glycosylation.
• Storage Temp
  -20°C
• Shipping
  Gel Pack
• Shelf Life
  12 months
• Appearance
  Lyophilized
• Physical form description
  Lyophilized from 0.22 um filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
• Reconstitution Instructions
  Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
• Background Information
  SLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), Membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Isoform 1 of SLAMF7 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion. Isoform 3 of SLAMF7 does not mediate any NK cell activation.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CellExp™   CD319   SLAMF7   CRACC  
• Gene symbol
  SLAMF7
• Short name
  CellExp™ CD319 / SLAMF7 / CRACC, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Humans
• Alternative name
  H. sapiens CellExp™ CD319 / SLAM family member 7 / CRACC, H. sapiens Rec.
• Alternative technique
  rec
• Alternative to gene target
  SLAM family member 7, SLAMF7 and IDBG-104088 and ENSG00000026751 and 57823, protein binding, Cell surfaces, Slamf7 and IDBG-204760 and ENSMUSG00000038179 and 75345, SLAMF7 and IDBG-630522 and ENSBTAG00000001197 and 790164

Gene info

• Identity
  HGNC:21394
• Gene
  SLAMF7
• Long gene name
  SLAM family member 7
• Synonyms
  • CRACC
  • 19A
  • CS1
  • CD319
• GenBank acession
  • AB027233
• Locus
  1q23.3
• Discovery year
  2003-10-29
• Entrez gene record
  57823
• Pubmed identfication
  • 11802771
  • 11220635
• RefSeq identity
  • NM_021181
• Classification
  • CD molecules
  • V-set domain containing
• VEGA ID
  OTTHUMG00000024008

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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