Axin1 Antibody

• Catalog number
  bs-2439R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Axin1 Primary Polyclonal Antibody
• Also known as
  Axin1 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Axin1
• Specificity
  This is a highly specific antibody against Axin1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  830-862/862
• Subcellular location
  Cytoplasm, Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Axin1
• Gene ID number
  8312
• Swiss Prot
  O15169
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  AXIN; PPP1R49; Axin-1; Axis inhibition protein 1; hAxin; AXIN1
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Axin1  
• Gene symbol
  AXIN1, CSRNP1
• Short name
  Anti-Axin1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Axin1 Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  axin 1, AXIN and PPP1R49, AXIN1 and IDBG-7404 and ENSG00000103126 and 8312, R-SMAD binding, nuclei, Axin1 and IDBG-154815 and ENSMUSG00000024182 and 12005, AXIN1 and IDBG-633677 and ENSBTAG00000016577 and 504357

Gene info

• Identity
  HGNC:903
• Gene
  AXIN1
• Long gene name
  axin 1
• Synonyms
  • PPP1R49
• Synonyms name
  • protein phosphatase 1, regulatory subunit 49
• GenBank acession
  • AF009674
• Locus
  16p13.3
• Discovery year
  1998-09-17
• Entrez gene record
  8312
• Pubmed identfication
  • 9230313
• Classification
  • Protein phosphatase 1 regulatory subunits
• VEGA ID
  OTTHUMG00000064930

Gene info

• Identity
  HGNC:14300
• Gene
  CSRNP1
• Long gene name
  cysteine and serine rich nuclear protein 1
• Synonyms gene
  • AXUD1
• Synonyms gene name
  • AXIN1 up-regulated 1
  • cysteine-serine-rich nuclear protein 1
• Synonyms
  • URAX1
  • DKFZp566F164
  • FAM130B
  • TAIP-3
• GenBank acession
  • AB053121
• Locus
  3p22.2
• Discovery year
  2001-01-03
• Entrez gene record
  64651
• Pubmed identfication
  • 11526492
  • 17726538
• RefSeq identity
  • NM_033027
• VEGA ID
  OTTHUMG00000131293

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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