HDAC4 Antibody

• Catalog number
  3604-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  HDAC4
• Target Alternative Name
  HDAC4 , HD4 , HDAC-A, KIAA0288 , HDACA , HA6116
• Antibody Type
  Polyclonal
• Species Reactivities
  Human, mouse, rat
• Immunogen Sequence
  Synthetic peptide corresponding to residues surrounding amino acid 10 of human HDAC-4
• Accession
  NP_006028
• Gene Id
  9759
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  0.5 mg/ml
• Formulation
  100 µg (0.5 mg/ml) affinity purified rabbit anti-HDAC4 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% sodium azide.
• Purification
  Affinity purified
• Application
  Western blot, and Immunohistochemistry
• Application And Usages
  Western blotting (1 µg/ml) and Immunohistochemistry (5 µg/ml). However, the optimal conditions should be determined individually. The antibody detects ~140 kDa HDAC-4. It does not cross-react with other HDAC proteins including HDAC1, 2, 3, 5, 6, 7, and 8.
• Description
  HDAC4 is a member of the class II mammalian histone deacetylases, which consists of 1084 amino acid residues. Its C-terminal sequence is highly similar to the deacetylase domain of yeast HDA1. HDAC4, unlike other deacetylases, shuttles between the nucleus and cytoplasm in a process involving active nuclear export. Association of HDAC4 with 14-3-3 results in sequestration of HDAC 4 protein in the cytoplasm. In the nucleus, HDAC4 associates with the myocyte enhancer factor MEF2A. Binding of HDAC4 to MEF2A results in the repression of MEF2A transcriptional activation. HDAC4 has also been shown to interact with other deacetylases such as HDAC3 as well as the corepressors NcoR and SMART.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  HDAC4  
• Gene symbol
  HDAC4-AS1, HDAC4
• Short name
  HDAC4 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  histone deacetylase 4 (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  histone deacetylase 4, AHO3 and BDMR and HA6116 and HD4 and HDAC-4 and HDAC-A and HDACA, HDAC4 and IDBG-84594 and ENSG00000068024 and 9759, NAD-dependent histone deacetylase activity (H3-K18 specific), nuclei, Hdac4 and IDBG-181579 and ENSMUSG00000026313 and 208727, HDAC4 and IDBG-642244 and ENSBTAG00000017764 and 517559

Gene info

• Identity
  HGNC:54064
• Gene
  HDAC4-AS1
• Long gene name
  HDAC4 antisense RNA 1
• Locus
  2q37.3
• Discovery year
  2018-09-27
• Entrez gene record
  101928111
• RefSeq identity
  • NR_135575
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:14063
• Gene
  HDAC4
• Long gene name
  histone deacetylase 4
• Synonyms gene
  • BDMR
• Synonyms gene name
  • brachydactyly-mental retardation syndrome
• Synonyms
  • KIAA0288
  • HDAC-A
  • HDACA
  • HD4
  • HA6116
  • HDAC-4
• GenBank acession
  • AB006626
• Locus
  2q37.3
• Discovery year
  2000-11-28
• Entrez gene record
  9759
• Pubmed identfication
  • 10206986
  • 10220385
  • 20691407
• RefSeq identity
  • NM_006037
• Classification
  • Histone deacetylases, class IIA
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000133344

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

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