Enzastaurin (LY317615)

  • Catalog number
    1619-5
  • Price
    Please ask
  • Size
    5 mg
  • Alternative_name
    LY317615, LY-317615, D04015
  • Description
    Enzastaurin (Enz) is a potent and selective inhibitor of PKCβ with antiproliferative activity (IC₅₀= ~6 nM). Enz suppresses VEGF-induced angiogenesis in the rat corneal micropocket assay, decreases microvessel density, and prevents VEGF secretion from human tumor cell xenografts in nude mice. Prolonged courses of Enz increase chemotherapy or radiation tumor growth delay of glioma, breast, and small cell lung cancer xenografts.
  • CAS Number
    170364-57-5
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₃₂H₂₉N₅O₂
  • Molecular Weight
    515.61
  • Cell Permeable
    Yes
  • Purity
    ≥99% by HPLC
  • Solubilities
    DMSO (5 mg/ml)
  • Handling
    Protect from air and light
  • Tag Line
    A PKC beta inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    RT
  • Shelf Life
    24months
  • MDL Number
    MFCD11040980
  • PubChem CID
    176167
  • SMILES
    CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)C6CCN(CC6)CC7=CC=CC=N7
  • InChi
    InChI=1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31 (29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7- 15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39)
  • InChi Key
    AXRCEOKUDYDWLF-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Gene target
  • Short name
    Enzastaurin (LY317615)
  • Alternative name
    Enzastaurin (LY317615)
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