Enzastaurin (LY317615)
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Catalog number1619-1
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PricePlease ask
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Size1 mg
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Alternative_nameLY317615, LY-317615, D04014
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DescriptionEnzastaurin (Enz) is a potent and selective inhibitor of PKCβ with antiproliferative activity (IC₅₀= ~6 nM). Enz suppresses VEGF-induced angiogenesis in the rat corneal micropocket assay, decreases microvessel density, and prevents VEGF secretion from human tumor cell xenografts in nude mice. Prolonged courses of Enz increase chemotherapy or radiation tumor growth delay of glioma, breast, and small cell lung cancer xenografts.
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CAS Number170364-57-5
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₃₂H₂₉N₅O₂
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Molecular Weight515.61
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Cell PermeableYes
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Purity≥99% by HPLC
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SolubilitiesDMSO (5 mg/ml)
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HandlingProtect from air and light
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Tag LineA PKC beta inhibitor
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Storage Condition-20°C
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Shipping ConditionRT
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Shelf Life24months
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MDL NumberMFCD11040980
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PubChem CID176167
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SMILESCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)C6CCN(CC6)CC7=CC=CC=N7
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InChiInChI=1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31 (29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7- 15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39)
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InChi KeyAXRCEOKUDYDWLF-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameEnzastaurin (LY317615)
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Alternative nameEnzastaurin (LY317615)
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