A-803467, NaV1.8 blocker

  • Catalog number
    SIH-304-50MG
  • Price
    Please ask
  • Size
    50 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    944261-79-4
  • Description
    NaV1.8 blocker
  • Molecular weight
    357,79 g/mol
  • Primary research fields
    Neuroscience, Ion Channels, Sodium Channels
  • Other name
    5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furamide
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C19H16ClNO4
  • Origin
    Synthetic
  • Purity pourcentage
    >98%
  • Soluble in
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Physical appearance
    Beige Solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H3012
  • PubChem number
    16038374
  • Scientific context
    A selective blocker of Nav1.8 channels. A-803467 potently reduced thermal hyperalgesia in inflammatory models of pain and mechanical allodynia in neuropathic models of pain, but was relatively ineffective in a skin-incision model of postoperative pain, a chemotherapy induced pain, and in visceral pain (1).
  • Bibliography
    1. Rush A.M., Cummins T.R. (2007) Mol Interv. 7(4): 192-195.
  • Release date
    8-Apr-2011
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of A-803467 (SIH-304), a NaV1.8 blocker. CAS #: 944261-79-4. Molecular Formula: C19H16ClNO4. Molecular Weight: 357.79 g/mol. Chemical structure of A-803467, a NaV1.8 blocker (SIH-304). CAS # 944261-79-4. Molecular Formula: C19H16ClNO4.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.05
  • Gene target
    A-803467   NaV1   blocker  
  • Gene symbol
    HLA-A, IGHV5-10-1, CIDEA, RPA1, CDC37P1, OR1Q1, FABP4, LINC01139, GTF2E1
  • Short name
    A-803467, NaV1 8 blocker
  • Alternative name
    A-803467, NaV1.8 blocker
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    immunoglobulin heavy variable 5-10-1
  • Synonyms gene
  • Synonyms gene name
    • immunoglobulin heavy variable 5-A (provisional, gene/pseudogene)
    • immunoglobulin heavy variable 5-A (provisional)
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2000-04-04
  • Entrez gene record
  • RefSeq identity
  • Classification
    • Immunoglobulin heavy locus at 14q32.33
  • VEGA ID
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    general transcription factor IIE subunit 1
  • Synonyms gene name
    • general transcription factor IIE, polypeptide 1 (alpha subunit, 56kD)
    • general transcription factor IIE, polypeptide 1, alpha 56kDa
  • Synonyms
  • Synonyms name
  • GenBank acession
  • Locus
  • Discovery year
    1993-08-20
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • General transcription factor IIE complex subunits
  • VEGA ID
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