A-803467, NaV1.8 blocker
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Catalog numberSIH-304-50MG
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PricePlease ask
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Size50 mg
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Stock availabilitIn StockIn Stock
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CAS number944261-79-4
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DescriptionNaV1.8 blocker
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Molecular weight357,79 g/mol
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Primary research fieldsNeuroscience, Ion Channels, Sodium Channels
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Other name5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furamide
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Product categorySmall Molecules
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Product typeInhibitor
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Chemical formulaC19H16ClNO4
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OriginSynthetic
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Purity pourcentage>98%
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Soluble inSoluble to 100 mM in DMSO and to 25 mM in ethanol
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Physical appearanceBeige Solid
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Storage recommendations-20ºC
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Shipping recommendationsShipped Ambient
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Safety informationClassification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H3012
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PubChem number16038374
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Scientific contextA selective blocker of Nav1.8 channels. A-803467 potently reduced thermal hyperalgesia in inflammatory models of pain and mechanical allodynia in neuropathic models of pain, but was relatively ineffective in a skin-incision model of postoperative pain, a chemotherapy induced pain, and in visceral pain (1).
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Bibliography1. Rush A.M., Cummins T.R. (2007) Mol Interv. 7(4): 192-195.
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Release date8-Apr-2011
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Representative figure legendChemical structure of A-803467 (SIH-304), a NaV1.8 blocker. CAS #: 944261-79-4. Molecular Formula: C19H16ClNO4. Molecular Weight: 357.79 g/mol. Chemical structure of A-803467, a NaV1.8 blocker (SIH-304). CAS # 944261-79-4. Molecular Formula: C19H16ClNO4.
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.05
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Gene target
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Gene symbolHLA-A, IGHV5-10-1, CIDEA, RPA1, CDC37P1, OR1Q1, FABP4, LINC01139, GTF2E1
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Short nameA-803467, NaV1 8 blocker
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Alternative nameA-803467, NaV1.8 blocker
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Gene info
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Identity
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Gene
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Long gene namemajor histocompatibility complex, class I, A
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C1-set domain containing
- Histocompatibility complex
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy variable 5-10-1
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Synonyms gene
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Synonyms gene name
- immunoglobulin heavy variable 5-A (provisional, gene/pseudogene)
- immunoglobulin heavy variable 5-A (provisional)
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-04
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin heavy locus at 14q32.33
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecell death inducing DFFA like effector a
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Synonyms gene name
- cell death-inducing DFFA-like effector a
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-07-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namereplication protein A1
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Synonyms gene name
- replication protein A1 (70kD)
- replication protein A1, 70kDa
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Synonyms
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GenBank acession
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Locus
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Discovery year1993-12-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Nucleotide excision repair
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecell division cycle 37 pseudogene 1
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Synonyms gene name
- cell division cycle 37 homolog (S. cerevisiae) pseudogene 1
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Synonyms
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Locus
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Discovery year2009-01-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameolfactory receptor family 1 subfamily Q member 1
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Synonyms gene
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Synonyms gene name
- olfactory receptor, family 1, subfamily Q, member 1
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Synonyms
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Locus
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Discovery year1999-12-09
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Entrez gene record
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Classification
- Olfactory receptors, family 1
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namefatty acid binding protein 4
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1991-08-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Fatty acid binding protein family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namelong intergenic non-protein coding RNA 1139
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Synonyms
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Synonyms name
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Locus
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Discovery year2013-12-03
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Long intergenic non-protein coding RNAs
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namegeneral transcription factor IIE subunit 1
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Synonyms gene name
- general transcription factor IIE, polypeptide 1 (alpha subunit, 56kD)
- general transcription factor IIE, polypeptide 1, alpha 56kDa
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1993-08-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- General transcription factor IIE complex subunits
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VEGA ID