Recombinant Human Fms-Related Tyrosine Kinase 3 Ligand/FLT3LG Protein(C-6His)
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Catalog number
PKSH032452-10µg
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Price
Please ask
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Size
10µg
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Synonym
Fms-Felated Tyrosine Kinase 3 Ligand; Flt3 Ligand; Flt3L; SL Cytokine; FLT3LG
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Activity
NA
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Sequence
Thr27-Pro184
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Fusion tag
C-6His
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Accession
P49771
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Expressed Host
Human cells
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Shipping
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
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Purity
＞95% as determined by reducing SDS-PAGE.
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Endotoxin
＜1.0 EU per µg as determined by LAL test.
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Stability and Storage
Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
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Mol Mass
18.9 kDa
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AP Mol Mass
24-32 kDa
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Formulation
Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl，pH8.0.
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Background
Fms-Related Tyrosine Kinase 3 Ligand (FLT3LG) is a hematopoietic four helical bundle cytokine. Mature human Flt-3 Ligand consists of a extracellular domain (ECD) with a cytokine-like domain and a juxtamembrane tether region, a transmembrane segment, and a cytoplasmic tail. Human and mouse Flt-3 Ligand show cross-species activity. Flt-3 Ligand is expressed as a noncovalently-linked dimer by T cells and bone marrow and thymic fibroblasts.It is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). In synergy with other growth factors, Flt3 ligand stimulates the proliferation and differentiation of various blood cell progenitors by activiation of Flt 3 receptor.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Description
FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
FLT3LG
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Short name
Recombinant Fms- Tyrosine Kinase 3 Ligand/FLT3LG Protein(C-6His)
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Species
Human, Humans
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Alternative name
Rec. H. sapiens Fms-Related Tyrosine phosphorylation catalyst 3 Ligand/fms-related tyrosine phosphorylation catalyst 3 ligand Protein(C-6His)
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Alternative technique
rec
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Alternative to gene target
fms-related tyrosine kinase 3 ligand, FL and FLT3L, FLT3LG and IDBG-62803 and ENSG00000090554 and 2323, protein homodimerization activity, Extracellular, Flt3l and IDBG-488510 and ENSMUSG00000089989 and 14256, FLT3LG and IDBG-640541 and ENSBTAG00000038045 and 282233
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Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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