Puromycin Dihydrochloride

  • Catalog number
    1860-100
  • Price
    Please ask
  • Size
    100 mg
  • Alternative_name
    3′-[α-Amino-p-methoxyhydrocinnamamido]-3′-deoxy-N,N-dimethyladenosine dihydrochloride
  • Description
    A nucleoside antibiotic. It inhibits protein synthesis by disrupting peptide transfer on ribosomes causing premature chain termination during translation. It is a potent translational inhibitor in both prokaryotic and eukaryotic cells. Resistance to puromycin is conferred by the puromycin N-acetyl-transferase gene (pac) from Streptomyces. Puromycin has a fast mode of action, causing rapid cell death at low antibiotic concentrations. Adherent mammalian cells are sensitive to concentrations of 2 to 5 µg/ml, while cells in suspension are sensitive to concentrations as low as 0.5 to 2 µg/ml.
  • CAS Number
    58-58-2
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₂₂H₂₉N₇O₅ · 2HCl
  • Molecular Weight
    544.43
  • Cell Permeable
    No
  • Purity
    ≥98% by HPLC
  • Solubilities
    H₂O (~50 mg/ml)
  • Handling
    Protect from air and moisture
  • Tag Line
    A protein synthesis inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    24 months
  • MDL Number
    MFCD00012691
  • PubChem CID
    16757772
  • SMILES
    CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)NC(=O)C(CC4=CC=C(C=C4)OC)N)O.Cl.Cl
  • InChi
    InChI=1S/C22H29N7O5.2ClH/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12;;/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32);2*1H
  • InChi Key
    MKSVFGKWZLUTTO-UHFFFAOYSA-N
  • MSDS Available
    Yes
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