Puromycin Dihydrochloride
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Catalog number
1860-100
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Price
Please ask
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Size
100 mg
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Alternative_name
3′-[α-Amino-p-methoxyhydrocinnamamido]-3′-deoxy-N,N-dimethyladenosine dihydrochloride
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Description
A nucleoside antibiotic. It inhibits protein synthesis by disrupting peptide transfer on ribosomes causing premature chain termination during translation. It is a potent translational inhibitor in both prokaryotic and eukaryotic cells. Resistance to puromycin is conferred by the puromycin N-acetyl-transferase gene (pac) from Streptomyces. Puromycin has a fast mode of action, causing rapid cell death at low antibiotic concentrations. Adherent mammalian cells are sensitive to concentrations of 2 to 5 µg/ml, while cells in suspension are sensitive to concentrations as low as 0.5 to 2 µg/ml.
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CAS Number
58-58-2
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₂H₂₉N₇O₅ · 2HCl
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Molecular Weight
544.43
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Cell Permeable
No
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Purity
≥98% by HPLC
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Solubilities
H₂O (~50 mg/ml)
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Handling
Protect from air and moisture
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Tag Line
A protein synthesis inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
24 months
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MDL Number
MFCD00012691
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PubChem CID
16757772
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SMILES
CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)NC(=O)C(CC4=CC=C(C=C4)OC)N)O.Cl.Cl
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InChi
InChI=1S/C22H29N7O5.2ClH/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12;;/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32);2*1H
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InChi Key
MKSVFGKWZLUTTO-UHFFFAOYSA-N
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MSDS Available
Yes
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