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Target antigen
TrkB
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human
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Analyses
WB
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Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human TrkB(70-90aa EIFIANQKRLEIINEDDVEAY), different from the related mouse and rat sequences by one amino acid.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the TrkB Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The TrkB Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
TrkB is also known as NTRK2. This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. Tropomyosin receptor kinase B is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations. The neurotrophins that activate TrkB are: BDNF (Brain Derived Neurotrophic Factor), neurotrophin-4 (NT-4), and neurotrophin-3 (NT-3). As such, TrkB mediates the multiple effects of these neurotrophic factors, which includes neuronal differentiation and survival.
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Related articles
1. Berghuis, P., Dobszay, M. B., Wang, X., Spano, S., Ledda, F., Sousa, K. M., Schulte, G., Ernfors, P., Mackie, K., Paratcha, G., Hurd, Y. L., Harkany, T. Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the NTRK2 receptor. Proc. Nat. Acad. Sci. 102: 19115-19120, 2005. 2. Luberg, K., Wong, J., Weickert, C. S., Timmusk, T. Human NTRK2 gene: novel alterative transcripts, protein isoforms and expression pattern in the prefrontal cerebral cortex during postnatal development. J. Neurochem. 113: 952-964, 2010. 3. Nikoletopoulou, V., Lickert, H., Frade, J. M., Rencurel, C., Giallonardo, P., Zhang, L., Bibel, M., Barde, Y.-A. Neurotrophin receptors TrkA and TrkC cause neuronal death whereas NTRK2 does not. Nature 467: 59-63, 2010.
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Gene Name
NTRK2
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Protein Name
BDNF/NT-3 growth factors receptor
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Gene Full Name
neurotrophic tyrosine kinase, receptor, type 2
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Synonyms
AI848316 antibody|BDNF tropomyosine receptor kinase B antibody|BDNF/NT 3 growth factors receptor antibody|BDNF/NT-3 growth factors receptor antibody|Brain derived neurotrophic factor receptor antibody|C030027L06Rik antibody|EC 2.7.10.1 antibody|GP145 TrkB antibody|GP145-TrkB antibody|GP145-TrkB/GP95-TrkB antibody|GP95 TrkB antibody|Neurotrophic tyrosine kinase receptor type 2 antibody|Neurotrophin receptor tyrosine kinase type 2 antibody|NTRK 2 antibody|NTRK2 antibody|NTRK2_HUMAN antibody|Obesity, hyperphagia, and developmental delay, included antibody|RATTRKB1 antibody|Tkrb antibody|Trk B antibody|Trk-B antibody|TRKB antibody|TrkB tyrosine kinase antibody|TRKB1 antibody|Tropomyosin related kinase B antibody|tyrosine kinase receptor B antibody|Tyrosine receptor kinase B antibody
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Uniprot ID
Q16620
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
