BIBX-1382
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Catalog number9463-25
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PricePlease ask
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Size25 mg
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Alternative_nameN8-(3-chloro-4-fluorophenyl)-N2-(1-methylpiperidin-4-yl)pyrimido[5,4-d]pyrimidine-2,8-diamine
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DescriptionBIBX 1382 is a potent, selective, reversible and ATP-competitive inhibitor of EGFR tyrosine kinase (IC₅₀ = 3 nM); displays > 1000-fold lower potency against ErbB2 (IC₅₀ = 3.4 μM) and a range of other related tyrosine kinases (IC₅₀ > 10 μM).
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CAS Number196612-93-8
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Structure AvailableYes
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Molecular FormulaC₁₈H₁₉ClFN₇
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Molecular Weight387.84
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>20 mg/ml)
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HandlingProtect from air and light
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Tag LineAn EGFR tyrosine kinase inhibitor
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Storage Condition-20°C
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Shipping ConditionGel pack
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Shelf Life36 months
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PubChem CID6918508
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SMILESN1CCC(CC1)NC2=NC=C3C(=N2)C(=NC=N3)NC4=CC(=C(C=C4)F)Cl
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InChiInChI=1S/C18H19ClFN7/c1-27-6-4-11(5-7-27)25-18-21-9-15-16(26-18)17(23-10-22-15)24-12-2-3-14(20)13(19)8-12/h2-3,8-11H,4-7H2,1H3,(H,21,25,26)(H,22,23,24)
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InChi KeyFTFRZXFNZVCRSK-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameBIBX-1382
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Alternative nameBIBX-1382
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