BIBX-1382

  • Catalog number
    9463-25
  • Price
    Please ask
  • Size
    25 mg
  • Alternative_name
    N8-(3-chloro-4-fluorophenyl)-N2-(1-methylpiperidin-4-yl)pyrimido[5,4-d]pyrimidine-2,8-diamine
  • Description
    BIBX 1382 is a potent, selective, reversible and ATP-competitive inhibitor of EGFR tyrosine kinase (IC₅₀ = 3 nM); displays > 1000-fold lower potency against ErbB2 (IC₅₀ = 3.4 μM) and a range of other related tyrosine kinases (IC₅₀ > 10 μM).
  • CAS Number
    196612-93-8
  • Structure Available
    Yes
  • Molecular Formula
    C₁₈H₁₉ClFN₇
  • Molecular Weight
    387.84
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO (>20 mg/ml)
  • Handling
    Protect from air and light
  • Tag Line
    An EGFR tyrosine kinase inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    Gel pack
  • Shelf Life
    36 months
  • PubChem CID
    6918508
  • SMILES
    N1CCC(CC1)NC2=NC=C3C(=N2)C(=NC=N3)NC4=CC(=C(C=C4)F)Cl
  • InChi
    InChI=1S/C18H19ClFN7/c1-27-6-4-11(5-7-27)25-18-21-9-15-16(26-18)17(23-10-22-15)24-12-2-3-14(20)13(19)8-12/h2-3,8-11H,4-7H2,1H3,(H,21,25,26)(H,22,23,24)
  • InChi Key
    FTFRZXFNZVCRSK-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Gene target
  • Short name
    BIBX-1382
  • Alternative name
    BIBX-1382
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