Recombinant Mouse Osteoprotegerin / TNFRSF11B Protein (Fc Tag) 100µg
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Catalog number
PKSM040324-100µg
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Price
Please ask
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Size
100µg
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Activity
NA
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Synonym
Ocif;Opg;TR1
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Sequence
Met1-Leu401
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Fusion tag
C-Fc
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Accession
NP_032790.3
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Expressed Host
HEK293 Cells
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Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity
> 95 % as determined by SDS-PAGE.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass
70.2 kDa
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AP Mol Mass
70.2 kDa
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Formulation
Lyophilized from sterile PBS, pH 7.4
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Background
Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. Osteoprotegerin/TNFRSF11B acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. This protein may inhibit the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. Osteoprotegerin/TNFRSF11B also play a role in preventing arterial calcification, act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
TNFRSF11B, BTF3P11
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Short name
Recombinant Mouse Osteoprotegerin / TNFRSF11B Protein (Fc Tag) 100µg
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Technique
Recombinant, Mouse, FC, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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Host
mouse
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Label
Fc Tag
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Species
Mouse, Mouses
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Alternative name
Rec. Mouse Osteoprotegerin / tumor necrosis factor receptor superfamily, member 11b Protein (fragment c detection labelled) 100µg
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Alternative technique
rec, murine
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Alternative to gene target
tumor necrosis factor receptor superfamily, member 11b, OCIF and OPG and TR1, TNFRSF11B and IDBG-33675 and ENSG00000164761 and 4982, protein binding, Extracellular, Tnfrsf11b and IDBG-140472 and ENSMUSG00000063727 and 18383, TNFRSF11B and IDBG-644876 and ENSBTAG00000007423 and 523822
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Gene info
Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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